Publications by authors named "Samia Hendou"
Article Synopsis
- - HIV elite controllers possess CD4 + T cells that are highly effective in recognizing and responding to Gag antigens, which may help them resist HIV infection and depletion.
- - These controllers demonstrate advanced Th1 differentiation patterns, but show reduced levels of the CCR5 marker compared to treated patients, indicating a lower susceptibility to HIV entry.
- - Some controllers have genetic mutations that further limit CCR5 expression, while others may downregulate it functionally through interactions with high-avidity antigens, suggesting both genetic and functional mechanisms promote natural HIV control.
The rare patients who are able to spontaneously control HIV replication in the absence of therapy show signs of a particularly efficient cellular immune response. To identify the molecular determinants that underlie this response, we characterized the T cell receptor (TCR) repertoire directed at Gag293, the most immunoprevalent CD4 epitope in the HIV-1 capsid. HIV controllers from the ANRS CODEX cohort showed a highly skewed TCR repertoire that was characterized by a predominance of TRAV24 and TRBV2 variable genes, shared CDR3 motifs, and a high frequency of public clonotypes.
View Article and Find Full Text PDFBackground: To clarify early correlates and natural history of HIV long-term nonprogressors (LTNPs) since HIV diagnosis.
Methods: Patients enrolled in the French ANRS SEROCO/HEMOCO cohort with CD4 count >500 cells/mm3 at HIV diagnosis. LTNP status was defined as being asymptomatic, antiretroviral free, and with CD4 cell count >500 cells/mm3 for >8 years after HIV diagnosis.