Publications by authors named "Samia Gharra"
Article Synopsis
- RGS proteins, like RGS2, inactivate Gα subunits and regulate G protein-coupled signaling networks, with RGS2 exclusively interacting with Gα subunits.
- Research reveals that three specific residues in RGS2 influence its unique interaction mode with Gα, primarily via the Gα GTPase domain.
- The study identifies key residues in the Gα helical domain as crucial for RGS2 specificity, offering insights into G protein interactions that could aid in designing new drugs and understanding signaling pathways.
