Effects of vanillin on potassium bromate-induced neurotoxicity in adult mice: impact on behavior, oxidative stress, genes expression, inflammation and fatty acid composition.

Context: Vanillin is known to possess important antioxidant activity.

Objective: The current study was conducted to establish the therapeutic efficiency of vanillin against potassium bromate (KBrO)-induced depression-like behavior and oxidative stress in mice.

Material And Methods: Mice were exposed during 15 days either to potassium bromate (KBrO), KBrO+ vanillin or to only vanillin.

Vanillin mitigates potassium bromate-induced molecular, biochemical and histopathological changes in the kidney of adult mice.

The present study aimed to explore the ability of vanillin to ameliorate the adverse effects induced by potassium bromate (KBrO3) in the renal tissue. Our results showed a significant increase in hydrogen peroxide, superoxide anion, malondialdehyde, advanced oxidation protein product and protein carbonyl levels in the kidney of KBrO3 treated mice, compared with the control group. Nephrotoxicity was evidenced by a decrease in plasma uric acid and kidney glutathione levels, Na(+)-K(+)-ATPase, lactate dehydrogenase and catalase activities.

Altered hepatic mRNA expression of immune response-associated DNA damage in mice liver induced by potassium bromate: Protective role of vanillin.

Chronic exposure to potassium bromate (KBrO ), a toxic halogen existing widely in the environment, environment through contaminated drinking water, has become a global problem of public health. The present study investigates the protective role of vanillin against KBrO induced oxidative stress, distruption in inflammatory cytokines expression, DNA damage, and histopathological changes. Adult mice were exposed orally to KBrO (2g/L of drinking water) for 2 weeks The co-administration of vanillin to the KBrO -treated mice significantly prevented the plasma transaminases increase in.