Publications by authors named "Samia Ammar Aldwaik"
Article Synopsis
- AMPA receptors (AMPARs) play a key role in fast brain signaling, responding to glutamate, with a focus on calcium-permeable versions known as CP-AMPARs, influenced by auxiliary proteins.
- This review highlights the importance of these auxiliary subunits in modifying AMPAR function and their relationship to cognitive processes like learning and memory.
- Changes in these auxiliary proteins are linked to various neurological disorders, and targeting them could lead to new treatment options for complex brain conditions.
An optimal balance between excitatory and inhibitory transmission in the central nervous system provides essential neurotransmission for good functioning of the neurons. In the neurology field, a disturbed balance can lead to neurological diseases like epilepsy, Alzheimer's, and Autism. One of the critical agents mediating excitatory neurotransmission is α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors, which are concerned with synaptic plasticity, memory, and learning.
View Article and Find Full Text PDFThe neuropharmacological community has shown a strong interest in AMPA receptors as critical components of excitatory synaptic transmission during the last fifteen years. AMPA receptors, members of the ionotropic glutamate receptor family, allow rapid excitatory neurotransmission in the brain. AMPA receptors, which are permeable to sodium and potassium ions, manage the bulk of the brain's rapid synaptic communications.
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