Predictors and outcomes of premature rupture of membranes among pregnant women admitted to a teaching Hospital in Saudi Arabia: a cohort study.

Background: Premature rupture of the membrane (PROM), refers to rupture of the fetal membranes prior to the onset of regular uterine contractions. When this occurs at term (≥ 37 weeks of gestation), it is classified as PROM, whereas if it occurs before 37 weeks, it is termed preterm premature rupture of membranes (PPROM). PROM and PPROM are linked to adverse outcomes for both mother and newborn.

Aspergillus foetidus as a potent producer for β-galactosidase utilizing lemon peels and coffee waste powder: production optimization, purification, kinetic and thermodynamic characterization.

Background: The main obstacle facing the utilization of microbial enzymes in industrial applications is the high cost of production substrates. As a result of the mentioned different wastes (coffee powder waste, dates nawah powder, molokhia stems, pea peels, lemon peels, and corn cobs) were investigated as low-cost nutritional substrates for the production of microbial β-galactosidase in this study. The purification of the enzyme and its kinetic and thermodynamics were investigated.

Tuning the optical and photophysical characteristics of DR1 through mixing with JGB.

A dye mixture of Disperse red1 (DR1) and Janus green B (JGB) was prepared with different concentrations of the two dyes. The optical properties were studied for the two dyes and their mixtures in terms of the absorbance spectra. The direct optical energy gap in addition to the refractive index, extinction coefficient, dielectric constant and optical conductivity were estimated to the two dyes and their mixtures.

Date nawah powder as a promising waste for β-mannanase production from a new isolate Aspergillus niger MSSFW, statistically improving production and enzymatic characterization.

β-Mannanase producing fungus was isolated from coffee powder waste and identified as Aspergillus niger MSSFW (Gen Bank accession number OR668928). Dates nawah powder as industrial and agricultural waste was the most inducer of β-mannanase production. The Plackett-Burman and Central Composite designs were used to improve β-mannanase titer.

Clinical and genetic characteristics of disorders of sex development in Sudanese patients.

Given the scarce data on DSD in Sudan, we aimed to characterize DSD's clinical and genetic profile in Sudanese patients. We studied 60 patients with DSD using clinical data, cytogenetics, and PCR for the SRY gene. The results showed that 65% grew up as females and 35% as males.

Thymoquinone Nanoparticles (TQ-NPs) in Kidney Toxicity Induced by Ehrlich Ascites Carcinoma (EAC): An In Vivo Study.

Background: Cisplatin (Cis) is potent chemotherapy used to treating already many different types of cancer; however, it is found to correlate with nephrotoxicity and other adverse health consequences. Thymoquinone (TQ) is an antioxidant and anti-inflammatory molecule that may defend against the consequences of different chemotherapies. Thymoquinone uses, although, are negatively impacted by its weak solubility and inadequate biological availability.

Portulaca oleracea L seed extracts counteract diabetic nephropathy through SDF-1/IL10/PPARγ-mediated tuning of keap1/Nrf2 and NF-κB transcription in Sprague Dawley rats.

Background & Objective: While oxidative stress is the key player driving diabetic nephropathy (DN), firm glycemic control remains the pillar prophylactic measure. Purslane was extensively described as a potent hypoglycemic and hypolipidemic agent owing to its rich content of antioxidants. Therefore, this report aimed to assess the renoprotective potentials of methanol (MO) and methylene chloride (MC) fixed oil extracts of purslane seeds in a diabetic nephropathy (DN) model.

Synthesis and Spectroscopic Characterization of Schiff Base Metal Complexes, Biological Activity, and Molecular Docking Studies.

New cobalt(II), copper(II), and zinc(II) Schiff metal complexes were synthesized by the condensation reaction of 4-nitrobenzene-1,2-diamine with 3-4-(diethylamino)-2-hydroxybenzaldehyde. Fourier transform infrared, nuclear magnetic resonance, ultraviolet-visible, electron paramagnetic resonance, and high-resolution electrospray ionization mass spectrometry and powder X-ray diffraction were used to characterize the synthesized HL and its metal complexes. Conductance measurements, magnetic moment estimation, and metal estimation have all been determined and discussed.

Neonatal Birthweight Spectrum: Maternal Risk Factors and Pregnancy Outcomes in Saudi Arabia.

Low-birth-weight (LBW) neonates are at increased risk of morbidity and mortality which are inversely proportional to birth weight, while macrosomic babies are at risk of birth injuries and other related complications. Many maternal risk factors were associated with the extremes of birthweight. The objectives of this study are to investigate maternal risk factors for low and high birthweight and to report on the neonatal complications associated with abnormal birth weights.

Evaluation of lupine seeds (Lupinus albus L.) neutral extract as a texture improver in low-fat yogurt production.

Aqueous lupine seeds (Lupinus albus L.) extracts were evaluated as a natural fat substitute in low-fat yogurt production. Thus, the chemical composition, particle size, molecular weight, total phenolic (TPC), and total flavonoids (TFC) of the selected extract were estimated.

Designing Thieno[3,4-]pyrrole-4,6-dione Core-Based, A-D-A-D-A-Type Acceptor Molecules for Promising Photovoltaic Parameters in Organic Photovoltaic Cells.

Nonfullerene-based organic solar cells can be utilized as favorable photovoltaic and optoelectronic devices due to their enhanced life span and efficiency. In this research, seven new molecules were designed to improve the working efficiency of organic solar cells by utilizing a terminal acceptor modification approach. The perceived configuration-based molecules possess a lower band gap ranging from 1.

Multistage approach to identify novel quinoline derivatives as potential c-kit kinase inhibitors.

The type II-C-KIT signaling network has been extensively studied for its potential as a target for cancer treatment, leading to the investigation of quinoline derivatives as compounds with inhibitory effects on c-Kit kinase. In this study, a multistage approach was employed, including the creation of pharmacophore models, 3D QSAR analysis, virtual screening, docking investigations, and molecular dynamics stimulation. The pharmacophore evaluation included a data set of 29 ligands, which resulted in the generation of the ADDHR_1pharmacophore model as the most promising, with a survival score of 5.

Evolutionary Computing for the Radiative-Convective Heat Transfer of a Wetted Wavy Fin Using a Genetic Algorithm-Based Neural Network.

Evolutionary algorithms are a large class of optimization techniques inspired by the ideas of natural selection, and can be employed to address challenging problems. These algorithms iteratively evolve populations using crossover, which combines genetic information from two parent solutions, and mutation, which adds random changes. This iterative process tends to produce effective solutions.

Sn-based materials in photocatalysis: A review.

Development and the application of Sn-based materials have become more prevalent in recent years due to concerns regarding the energy crisis, environmental pollution, and the urgent need of constructing inexpensive and highly effective photocatalysis. The recent advancement in Sn-based materials for efficient photocatalysts, such as Sn alloys, Sn oxides, Sn sulfides, Sn selenides, Sn niobates, Sn tantalites, and Sn tungstates, is summarized in this study. Several design ideas for increasing the photoactivity of Sn-based materials in various photocatalytic applications are emphasized.

Heat transfer analysis in magnetohydrodynamic nanofluid flow induced by a rotating rough disk with non-Fourier heat flux: aspects of modified Maxwell-Bruggeman and Krieger-Dougherty models.

Non-Newtonian fluids have unique heat transfer properties compared to Newtonian fluids. The present study examines the flow of a Maxwell nanofluid across a rotating rough disk under the effect of a magnetic field. Furthermore, the Cattaneo-Christov heat flux model is adopted to explore heat transport features.

Effect of dexamethasone administration on gonadal-fertility functions in female albino rats.

Introduction: dexamethasone is misused for skin whitening with broad effects on steroidogenesis and ovarian functions. Here in we investigated the impact of dexamethasone administration on gonadotropin Luteinizing Hormone (LH) and Follicle Stimulating Hormone (FSH), prolactin, and ovarian tissues in albino rats.

Methods: in the experimental study, 36 female albino rats weighting (140-162 g) were divided into three groups: control, normal dose received dexamethasone (8.

Statistical optimization of enzyme cocktail production using Jew's mallow stalks residues by a new isolate Aspergillus flavus B2 via statistical strategy and enzymes characterization.

This study investigates the production of the enzyme cocktail by the isolated fungi Aspergillus flavus B2 (GenBank accession number OL655454) using agricultural and industrial (AI) residues as the sole substrate. Of all the AI residues tested, Jew's mallow stalk was the best inducer substrate for enzyme cocktail production without adding any nutrients. Statistical optimization using Response Surface Methodology enhanced the production by 5.

Comparative Study of the Effective Properties of 0-3 and Gyroid Triply Periodic Minimal Surface Cement-Piezocomposites.

In the present numerical simulation work, effective elastic and piezoelectric properties are calculated and a comparative study is conducted on a cement matrix-based piezocomposite with 0-3 and gyroid triply periodic minimal surface (TPMS) inclusions. The present study compares the effective properties of different piezoelectric materials having two different types of connectivity of the inclusions namely, 0-3 inclusions where the inclusions are physically separated from each other and are embedded within the matrix and the second one is TPMS inclusions having interpenetrating phase type connectivity. Effective properties are calculated for four different materials at five different volume fractions namely, 10%, 15%, 20%, 25%, and 30% volume fractions of inclusion by volume.

Antioxidant capacity and antitumor activity of the bioactive protein prepared from orange peel residues as a by-product using fungal protease.

Agricultural and industrial residues (AIR) are renewable biomass sources present in large quantities causing pollution. Converting AIR to eco-friendly products (bioactive materials) reduces their quantity and impact on the environment, in addition to reducing production costs. Therefore, orange peel (OP) protein degradation, antioxidant capacity, and antitumor activity were investigated using Aspergillus niger WA 2017 protease.

Protease immobilization on a novel activated carrier alginate/dextrose beads: Improved stability and catalytic activity via covalent binding.

Protease from Bacillus thuringiensis strain-MA8 was successfully immobilized onto activated Alginate/dextrose (Alg/dex) beads as a new carrier with immobilization yield 77.6 %. The carrier was characterized using Scanning electron microscopy and Fourier transforms infrared spectrophotometer at every step of the immobilization process.

Negative Poisson's ratio polyethylene matrix and 0.5Ba(Zr Ti) O-0.5(Ba Ca)TiO based piezocomposite for sensing and energy harvesting applications.

Finite element studies were conducted on 0.5Ba(Zr Ti) O-0.5(Ba Ca)TiO (BCZT) piezoelectric particles embedded in polyethylene matrix to create a piezocomposite having a positive and negative Poisson's ratio of -0.

Effect of Poling on Multicatalytic Performance of 0.5Ba(ZrTi)O-0.5(BaSr)TiO Ferroelectric Ceramic for Dye Degradation.

Ferroelectric materials with a spontaneous polarization are proven to be potential multicatalysts in water remediation applications. The composition of 0.5Ba(ZrTi)O-0.

Statistical improvement of protease production from a new isolate Bacillus thuringiensis strain-MA8 and its application in the production of enzyme-modified cheese.

Enzyme-modified cheese (EMC) is a concentrated cheese flavor that is produced enzymatically from dairy substrates to provide an intense source of cheese flavor with broad applications. In this study, EMC was produced by enzymatic biotransformation from a new bacterial isolate described and molecularly identified as Bacillus thuringiensis strain-MA8. Optimization of protease production conditions using one-variable-at-a-time followed by multi-factorial (Plackett-Burman and Box-Behnken) designs increased production by 7-fold.

In-silico Investigations of quinine and quinidine as potential Inhibitors of AKR1B1 and AKR1B10: Functional and structural characterization.

The aberrant expression of aldo keto reductases (AKR1B1 & AKR1B10) has been extensively studied in different types of cancer especially the colon cancer but a very few studies have yet been reported regarding the discovery of inhibitors for the treatment of colon cancer by targeting these isozymes. Therefore, there is a need of selective inhibitors of both targets for the eradication of colon cancer. Currently, the study is focused on the exploration of two quinolone compounds i.