Publications by authors named "Samia A Tawfik"
Three novel, simple and accurate multivariate spectrophotometric assisted mathematical techniques were developed for determination of paracetamol, caffeine, drotaverine HCl and their related impurities. The used multivariate algorithms are principal component regression (PCR), partial least squares (PLS), and synergy intervals partial least squares (siPLS). Linearity of the suggested methods was found to be (1.
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- A new eco-friendly reversed-phase HPLC method was developed to accurately measure paracetamol, caffeine, and drotaverine HCl, along with their impurities, using a specialized column and green mobile phase.
- The method adhered to rigorous international guidelines for validation, showing reliable linearity and precision across different concentration ranges for the studied drugs and their impurities.
- The method demonstrated compatibility with tablet formulations, yielded similar results to existing methods, and complied with green chemistry principles, as verified by multiple assessment tools.
Two specific, sensitive, rapid and accurate chromatographic methods have been developed, optimized and validated for the simultaneous determination of sulfacetamide sodium and prednisolone acetate in pure forms and in their binary mixture. The first method is an isocratic Reversed phase-high performance liquid chromatography method where a rapid separation was achieved on a Zorbax ODS column using a green mobile phase of methanol: water (80:20, v/v) and pH adjusted to 5.0 ± 0.
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