Association of serum-soluble CD26 and CD30 levels with asthma, lung function and bronchial hyper-responsiveness at school age.

Aim: There is a need for markers of Th1 and Th2 imbalance in diseases such as asthma. CD30 is an activation marker of Th2 cells, and importance of Th1 marker CD26 was recently found in adult asthma. We studied whether serum-soluble CD30 (sCD30) or serum-soluble CD26 (sCD26) could support early diagnosis of asthma in children at school age.

Comparison of quality of life between asthmatic and healthy school children.

There are only a few studies which have assessed the impact of asthma on the quality of life (QoL) compared to healthy children. In this study we wanted to compare QoL between asthmatic and healthy children in a population based setting. We surveyed 2159 children aged 11-15 yr with a Child Health Questionnaire; a generic QoL measure for children.

On roots of childhood asthma: the role of respiratory infections.

The prevalence of childhood asthma has increased throughout the last decades, but the reasons for the increase still remain unresolved. However, the debate has recently focused on the role of infections, and microbial exposure in general, in the development of childhood asthma. Many studies have suggested that there is an inverse relation between certain infections and the risk of asthma.

Hand-held turbine spirometer: agreement with the conventional spirometer at baseline and after exercise.

Portable hand-held spirometers are widely used in outpatient clinics and in field surveys when examining children for asthma. However, the validity of the results obtained from the hand-held spirometers has not been assessed in population-based studies. We evaluated the agreement between the forced expiratory volume (FEV1) values got by the conventional flow volume spirometer (FVS) and the pocket-sized turbine spirometer (TS) at baseline and after exercise, among the 212 children screened for asthma and asthma-like symptoms from a population of 1633 school-aged children.