Publications by authors named "Sami Remes"
Background: Bronchial hyperresponsiveness (BHR) and asthma are frequently present in children with food allergy. We assessed BHR in children receiving oral immunotherapy (OIT) for persistent egg or peanut allergy and examined whether OIT affects asthma control.
Methods: Methacholine challenge testing was performed in 89 children with persistent egg or peanut allergy diagnosed by double-blind, placebo-controlled food challenge and 80 control children without food allergy.
Article Synopsis
- Scientists are looking at how immunotherapy might help prevent asthma in kids and decided to check old study results about allergies and breathing problems in children.
- In a 1994 study in Finland, they tested 247 children, some with breathing issues and others who were healthy, to see how allergies affected their lung function.
- They found that kids with allergies showed more bronchial hyperresponsiveness (which means their airways reacted more) than those without symptoms, but it didn’t change breathing tests for those who were healthy.
Impulse oscillometry and free-running tests for diagnosing asthma and monitoring lung function in young children.
Ann Allergy Asthma Immunol
September 2021
Background: Separating individuals with viral-induced wheezing from those with asthma is challenging, and there are no guidelines for children under 6 years of age. Impulse oscillometry, however, is feasible in 4-year-old children.
Objective: To explore the use of impulse oscillometry in diagnosing and monitoring asthma in young children and evaluating treatment response to inhaled corticosteroid (ICS).
Eucapnic voluntary hyperventilation test decreases exhaled nitric oxide level in children.
Clin Physiol Funct Imaging
January 2021
Background: Exhaled nitric oxide (FeNO) measurements and eucapnic voluntary hyperventilation (EVH) tests have been used as diagnostic tools for asthma. Data on the impact of hyperventilation on the level of FeNO are limited.
Aim: We aimed to evaluate whether EVH tests affect the level of FeNO in children aged 10-16 years.
Cut-off values to evaluate exercise-induced asthma in eucapnic voluntary hyperventilation test for children.
Clin Physiol Funct Imaging
September 2020
Background And Aim: The eucapnic voluntary hyperventilation (EVH) testing is a diagnostic tool for diagnostics of exercise-induced bronchoconstriction; while the testing has become more common among children, data on the test's feasibility among children remain limited. Our aim was to investigate EVH testing feasibility among children, diagnostic testing cut-off values, and which factors affect testing outcomes.
Methods: We recruited 134 patients aged 10-16 years with a history of exercise-induced dyspnoea and 100 healthy control children to undergo 6-min EVH testing.
Context: Adrenarche is a gradual process, but its programming is unknown.
Objective: The objective of this article is to examine the trajectory of dehydroepiandrosterone sulfate (DHEAS) from age 1 to 6 years and the associations of early growth with DHEAS concentration by age 6 years.
Design And Participants: Longitudinal data from a population sample of 78 children (43 girls) with serum samples for DHEAS and insulin-like growth factor 1 (IGF-1) measurements available at ages 1 and 6 years.
Rhinovirus Type in Severe Bronchiolitis and the Development of Asthma.
J Allergy Clin Immunol Pract
February 2020
Background: Respiratory syncytial virus (RSV)- and rhinovirus (RV)-induced bronchiolitis are associated with an increased risk of asthma, but more detailed information is needed on virus types.
Objective: To study whether RSV or RV types are differentially associated with the future use of asthma control medication.
Methods: Over 2 consecutive winter seasons (2008-2010), we enrolled 408 children hospitalized for bronchiolitis at age less than 24 months into a prospective, 3-center, 4-year follow-up study in Finland.
Background: Early-life indoor bacterial exposure is associated with the risk of asthma, but the roles of specific bacterial genera are poorly understood.
Objective: We sought to determine whether individual bacterial genera in indoor microbiota predict the development of asthma.
Methods: Dust samples from living rooms were collected at 2 months of age.
Article Synopsis
- The study looked at how food allergies show symptoms in different parts of the body and what causes them, plus how to prevent allergies and help kids become tolerant to them.
- It found that food allergies can affect the skin, mouth, stomach, and even breathing or heart in serious cases, and there are two types of reactions: fast ones from IgE and slower ones that scientists don't fully understand yet.
- Eating a variety of foods is really important for kids, even if their families have a history of allergies.
Aim: This study investigated oral immunotherapy (OIT) for children aged 6-18 years with wheat allergies.
Methods: Well-cooked wheat spaghetti was given to 100 children with wheat allergies every day for 17 weeks, increasing from 0.3 to 2000 mg of wheat protein, followed by three- and nine-month maintenance phases.
Background: In children, exercise-induced dyspnea is a common symptom that can be due to dysfunctional breathing. EVH test has bee used especially in elite athletes as bronchoprovocation test. Currently, there are only few studies on the EVH test.
View Article and Find Full Text PDFAim: Infants hospitalised for bronchiolitis undergo examinations and treatments not supported by current research evidence and we investigated practice variations with regard to Finnish children under the age of two.
Methods: This prospective, multicentre cohort study was conducted in paediatric units in three university hospitals in Finland from 2008 to 2010. Hospital medical records were reviewed to collect data on clinical course, testing and treatment.
Importance: Atopic dermatitis is an inflammatory, pruritic skin disease that often occurs in early infancy with a chronic course. However, a specific description of subtypes of atopic dermatitis depending on the timing of onset and progression of the disease in childhood is lacking.
Objective: To identify different phenotypes of atopic dermatitis using a definition based on symptoms before age 6 years and to determine whether some subtypes are more at risk for developing other allergic diseases.
Article Synopsis
- This study examines the link between cord blood cytokine production and respiratory tract infections in infants during their first year, focusing on immune regulation factors.
- Researchers analyzed data from a birth cohort of 550 children from rural areas in Europe, assessing cytokine levels using blood samples and tracking infection symptoms through weekly diaries.
- Results indicate that higher levels of certain cytokines (IL-5 and IFN-γ) in cord blood are associated with fewer reports of middle ear infections, suggesting that stronger immune responses at birth may help protect against these types of infections.
Article Synopsis
- This study examined the link between viral infections during bronchiolitis and the use of asthma medications in children under 2 years old.
- Researchers followed 408 hospitalized children in Finland for a year, using PCR tests to identify the virus and conducting interviews to assess medication use.
- Results showed that children with rhinovirus bronchitis were much more likely to use asthma controller medication and systemic corticosteroids compared to those with other viruses or none identified.
In 169 Finnish infants hospitalized for bronchiolitis at age <6 months in 2008-2010, nasopharyngeal aspirates were tested by polymerase chain reaction for Bordetella pertussis and 16 viruses. Respiratory viruses were detected in 89% (71% with respiratory syncytial virus), but no infant had B. pertussis.
View Article and Find Full Text PDFThis guideline, targeted to healthcare workers dealing with food-allergic children, provides a review on the clinical aspects of pediatric food allergy. The main updates include: elimination diets are not recommended for breast-feeding mothers; probiotics are not recommended for allergy prevention or treatment; food challenges are the basis of the diagnosis, but it can be improved by IgE component diagnostics. The treatment for severe symptoms is specific food avoidance, mildly symptomatic children should continue with versatile diet.
View Article and Find Full Text PDFBackground: Excess moisture and visible mold are associated with increased risk of asthma. Only a few studies have performed detailed home visits to characterize the extent and location of moisture damage and mold growth.
Methods: Structured home inspections were performed in a birth cohort study when the children were 5 months old (on average).
Objective: To determine whether hospital length-of-stay (LOS) for bronchiolitis is influenced by the causative virus: respiratory syncytial virus (RSV) or rhinovirus.
Methods: This prospective study was carried out in 3 university hospitals in Finland during 2 consecutive winter seasons. We enrolled consecutive children <2 years of age hospitalized with an attending physician's diagnosis of bronchiolitis.
Article Synopsis
- - The study aimed to examine how interactions with dogs and cats during the first year of life influenced the occurrence of respiratory symptoms and infections in 397 children born in eastern or middle Finland between 2002 and 2005.
- - Results showed that children living with dogs experienced fewer respiratory issues and infections compared to those without dogs, suggesting that dog contacts may contribute to better health outcomes in this regard.
- - The findings support the idea that early exposure to pets, particularly dogs, may enhance a child's immune resistance against respiratory infections during infancy.
Congenital ciliary dysfunctions are recessively inherited disorders. The disorder is poorly recognized, if the patient has no situs inversus. The diagnosis is delayed, being made on the average at the age of over five years.
View Article and Find Full Text PDFArticle Synopsis
- Most babies with food allergies will get better as they grow up, but about 1 in 5 will still have allergies when they start school.
- Some new studies show that kids can become less allergic by slowly eating small amounts of the food they're allergic to.
- These studies are showing that 80% of kids either completely or partially get over their food allergies, which is a really good sign!
Aim: There is a need for markers of Th1 and Th2 imbalance in diseases such as asthma. CD30 is an activation marker of Th2 cells, and importance of Th1 marker CD26 was recently found in adult asthma. We studied whether serum-soluble CD30 (sCD30) or serum-soluble CD26 (sCD26) could support early diagnosis of asthma in children at school age.
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