Proteomics couples electrical remodelling to inflammation in a murine model of heart failure with sinus node dysfunction.

Aims: In patients with heart failure (HF), concomitant sinus node dysfunction (SND) is an important predictor of mortality, yet its molecular underpinnings are poorly understood. Using proteomics, this study aimed to dissect the protein and phosphorylation remodelling within the sinus node in an animal model of HF with concurrent SND.

Methods And Results: We acquired deep sinus node proteomes and phosphoproteomes in mice with heart failure and SND and report extensive remodelling.

Cardiac GR Mediates the Diurnal Rhythm in Ventricular Arrhythmia Susceptibility.

Background: Ventricular arrhythmias (VAs) demonstrate a prominent day-night rhythm, commonly presenting in the morning. Transcriptional rhythms in cardiac ion channels accompany this phenomenon, but their role in the morning vulnerability to VAs and the underlying mechanisms are not understood. We investigated the recruitment of transcription factors that underpins transcriptional rhythms in ion channels and assessed whether this mechanism was pertinent to the heart's intrinsic diurnal susceptibility to VA.

Symptomatic bradyarrhythmias in the athlete-Underlying mechanisms and treatments.

Bradyarrhythmias including sinus bradycardia and atrioventricular (AV) block are frequently encountered in endurance athletes especially at night. While these are well tolerated by the young athlete, there is evidence that generally from the fifth decade of life onward, such arrhythmias can degenerate into pathological symptomatic bradycardia requiring pacemaker therapy. For many years, athletic bradycardia and AV block have been attributed to high vagal tone, but work from our group has questioned this widely held assumption and demonstrated a role for intrinsic electrophysiological remodeling of the sinus node and the AV node.

Model Predictive Control with Integrated Model Reduction for a Continuous Lactide Ring-Opening Polymerization Process.

Poly(lactic acid) production has received increasing attention, mainly due to its inherent biodegradable thermoplastic properties and to its renewable-resource-based composition. This process is affected by changes in the operating conditions and by raw material impurities which influence the reaction rate and degrade the polymer properties. As the system model is multivariable with coupled dynamics and constraints, linear model predictive control (LMPC) is employed here.

Clinical Experience of the Efficacy and Safety of Low-dose Tolvaptan Therapy in a UK Tertiary Oncology Setting.

Context: In patients with cancer, hyponatremia is associated with increased morbidity and mortality and can delay systemic therapy.

Objective: To assess the safety and efficacy of low-dose tolvaptan (7.5 mg) for hospitalized, adult patients with hyponatremia due to syndrome of inappropriate antidiuresis (SIAD), and coexisting malignancy.

[The Usefulness of Clonazepam as an Augmentative Treatment in a Case of Severe Childhood Onset Obsessive-Compulsive Disorder].

The goal of this study is to report on the treatment of obsessive-compulsive disorder (OCD), a chronic disabling condition that often presents during childhood and adolescence. Reports on adults using clonazepam for the treatment of OCD are more numerous than on children. Clonazepam as an augmentative treatment in OCD is still controversial.

[Management of anorexia nervosa in a Tunisian case].

Background: Anorexia nervosa is a complex psychiatric illness that can lead to severe physical complications.

Objective: This work aimed to study the approach taken by the child psychiatry service of Razi hospital in the management of anorexia nervosa and to compare it with international recommendation.

Methods: We propose to illustrate by a case report and review international recommendations on this topic while undertaking a review of the literature based on a Medline search using the following keywords: anorexia, nervosa adolescence, management, guidelines.

[The Tunisian Revolution in the eyes of children].

Background: The child uses drawing as a language. By reflecting faithfully all that is involved in the psychic life of the child, the drawing participates in the diagnosis and plays a role in the therapeutic management of young people suffering from psychological difficulties.

Aim: To analyze the drawings of children and adolescents followed at the department of Child and Adolescent Psychiatry, further to the events of the Tunisian Revolution.

[Clinical characteristics of Rett Syndrome].

Background: Rett Syndrome is a neurodevelopmental disorder, one of the least commonly occurring autism spectrum disorders (ASD),affecting mainly females.

Aim: To describe features and molecular specificities of Rett syndrome.

Methods: To identify articles for this review, a Pubmed search was conducted using the following keywords: Rett syndrome, regression,mutation, stereotypes.

[Profile of a population of consultants in child psychiatry and access to care by gender].

Background: Access to care in mental health is a fundamental element in the monitoring and care of children and adolescents.

Aim: The objective of this work was to draw up the demographic and clinical characteristics of a population of consultants in child psychiatry and to investigate possible gender inequalities in access to care.

Methods: This is a descriptive cross-sectional study concerning a sample of 730 children and adolescents having consulted child psychiatry department in Tunis and Monastir during a period of 4 months (April-July on 2006).

[The mobile: a new addiction upon adolescents].

Aim: This survey was conducted to investigate mobile phone use and dependence in Tunisian high school students.

Methods: Questionnaires were anonymously distributed to 120 adolescents looking for the modalities of use of mobiles. SMS dependency was assessed with the French version of the Igarashi scale.

[The diagnosis of temporal epilepsy in child psychiatry: a report of 7 cases].

Aim: This paper attempts to describe the features of temporal epilepsy in patients firstly considered as having psychiatric disorders.

Methods: The cases of seven patients followed between 2005 and 2008 at the Child and Adolescent Psychiatry Department of Razi Hospital, aged 11 to 15 years are treated.

Results: All the patients showed complex partial seizures, and some of them showed secondarily generalized tonic-clonic seizures.

[Memory impairments during child and adolescent depression].

Aim: This study aimed to evaluate basic performances on verbal memory in treatment-naïve children and adolescents with depression and in healthy control subjects.

Methods: 34 children and adolescents aged 6-16 years, suffering from a first major depressive disorder (DSM IV) and 34 controls matched on sex, age and cognitive ability were evaluated. Psychiatric diagnosis was assessed with the K-SADS-PL.