Circulating MMP-7 and VEGF as potential predictive biomarkers for recurrent implantation failures.

Recurrent implantation failure (RIF) is considered to be one of the major limiting factors of assisted reproductive technology (ART) programme success. The current study focused on the investigation of matrix metalloproteinases (MMPs), tissue inhibitors of MMPs (TIMPs), cytokines and cell adhesion molecules in peripheral blood (PB) and follicular fluid (FF) obtained from 44 women aged between 25 and 39 years old and undergoing intracytoplasmic sperm injection (ICSI). These women were divided into two groups: 22 RIF women with embryo implantation failures after the transfer of at least four fresh or frozen-thawed good quality embryos in a minimum of three ICSI cycles, and 22 ICSI success women (controls) who achieved a clinical pregnancy at their first ICSI attempt.

[The opening of the internal cervical os predicts cervical ripening better than Bishop's score in nulliparous women at 41 weeks gestation].

Introduction: The objectif was to evaluate ultrasound measurement of the opening of the internal cervical os in the prediction of cervical ripening and to compare it with Bishop's score.

Methods: We conducted a prospective study of 77 nulliparous women admitted to hospital in labor at 41w gestation, with Bishop's Score < 6, over a 10-month period, between July 2012 and April 2013. The measurement of the opening of the internal cervical os was performed using transvaginal ultrasound and Bishop's score was determined by clinical examination.

[Early postpartum discharge: outcomes and risk factors of readmission].

The objective of this study is to evaluate the practice of early postpartum discharge by analyzing maternal readmission rates and identifying readmission risk factors. This is a prospective and analytical study of 1206 patients discharged from hospital on postpartum day 1. For each patient we collected the epidemiological data, the course of pregnancy and childbirth.

[Evaluation of different techniques for vaginoplasty in the treatment of Mayer-Rokitansky-Kuster-Hauser syndrome].

Background: Rokitansky syndrome is an utero-vaginal aplasia with a frequency of 1 / 5000 female births. To correct this anomaly whose prognosis is mainly functional and psychological numerous surgical techniques have been described.

Aims: To report our experience about 13 patients with Rokitansky syndrome and having benefited from a vaginoplasty between 1993 and 2008 and to evaluate the results of the various anatomical techniques.

Effects of hexavalent chromium on reproductive functions of male adult rats.

Hexavalent chromium is an environmental contaminant which may be associated with reproductive abnormalities in male rats. In the present study, we examined the effect of hexavalent chromium on male reproductive function of rats. Male Wistar rats received a daily intraperitoneal injection of potassium dichromate (1 or 2 mg/kg body weight) for fifteen consecutive days.

[Fibroids and pregnancy: complications].

Aim: To study the maternal and fetal morbidity in the association fibroid and pregnancy and the management in this case.

Methods: A retrospective study of 80 cases of fibroids associated to pregnancy. These cases were taken from the department "C" of gynecology and obstetrics in the center of maternity and neonatology of Tunis.

[Management of liver disease during pregnancy].

Background: Several liver diseases can be observed during pregnancy. Some are proper to pregnancy and others are not.

Aim: To study and to analyze the different liver diseases encountered during pregnancy and describe their management.

[Fine-wire localizations in non palpable breast lesions].

Background: Breast cancer represents a major health problem in Tunisia. Mammography allows screening and early diagnosis of breast cancer. The Harpoon allows the location of these small lesions in order to have a histological study and to adapt the management.

[Granulosa cell tumors: a study of 7 cases].

Background: The granulosa tumors have been described for the first time in 1855 by Rokitansky.

Aims: To investigate the epidemiological and pathological characteristics of granulosa tumors, and the prognostic factors to determine therapy management.

Methods: Our study is retrospective about 7 cases of granulosa cells tumors treated and monitored at the department C of Gynecology and Obstetrics in the Center of Maternity and Neonatology of Tunis.

[Management of postpartum vaginal haematomas by embolisation: two cases].

Postpartum vaginal haematomas are a rare complication of delivery. The incidence of large haematomas is estimated at 1/4000 deliveries, and this complication can be life-threatening. We report two such cases.

[Borderline tumors : diagnosis and management : report of 10 cases].

Background: Since their discovery in 1929 by Taylor border tumors of the ovary, also known as borderline tumor (TOLM) inspired confusion, apprehension and disagreement.

Aim: Identify epidemiological, clinical and therapeutic particularities of borderline tumors of the ovary. -Study the different surgical approaches for borderline tumors of the ovary.

[Perigenital hematoma. Diagnosis and management].

Objectives: Discuss the clinical aspects and the management of perigenital hematoma, a rare complication of delivery that can engage the vital prognosis.

Cases: We report 4 cases of peri-genital hematomas recorded in the department C of obstetrics and gynecology, in the maternity center of Tunis. In two cases, the patients had only medical treatment and in the two others arterial embolisation was performed.

[Prognosis of delivery from a scared uterus: 123 cases].

Background: During these last two decades, the practitioners are more and more confronted to pregnancies on scar womb.

Aim: To analyse the behaviour to be held in front of a scar womb and to estimate materno-foetal preview after childbirth (delivery) by vaginal delivery or after a caesarean section at cold.

Methods: It is about a retrospective study held over 123 cases of patients with a scar womb who gave birth in the department "C" of the CMNT over a period of 2 years.

[Management of ovarian cyst associated to pregnancy].

Background: The problem of the association of the ovarian cyst and pregnancy is to determine whether the cyst is functional or organic?

Aim: To draw up the epidemiological profile of the patients having a cyst of the ovary, show the peculiarities of this association; and to clarify the therapeutic methods and its effects on the progress of the pregnancy.

Methods: A retrospective study concerning a period of 5 years and interesting 25 patients.

Results: The average age of the patients was of 34 years, the average parity was of 2.

[Haemorrhage delivery. About 65 cases].

The delivery haemorrhage is actually a problem of public health. It is responsible of 31.5 % of the maternal death in Tunisia.

[Management of ectopic pregnancy. about 77 cases].

We report a retrospective study of 77 ectopic pregnancies, collected over a period of 5 years and 4 months. The aim of this study was to analyse the epidemiology, the clinical and special investigation findings of this pathology, and to report our result as regards management of ectopic pregnancy, eectopic pregnancy affects young women (mean age : 31.8 years), whether multiparous or pauciparous (81.

[Coelioscopy in gynecologic emergencies. About 239 cases].

Objective: The goal of this study was to determine the efficiency of lapaorscopy as method of diagnosis and treatment of gynecologic emergencie.

Methods: A laparoscopy was performed in two hundred and thirty-nine patients who presented in emergency with signs like acute pelvic pain, uterine bleeding or fever. Diagnoses and treatments are presented in a retrospective study.

[Emergency embolization in gynaecological bleeding. Two case reports].

Two patients with gynaecological hemorrhage underwent successfully trans-arterial embolization. The first womanhad an uncontrollable perineal hemorrhage following a delivery with forceps. Angiography showed extravasation of contrast from right and left vaginal artery.

[Fetal thoraco-omphalopagus. Prenatal ultrasonographic diagnosis at 15 weeks].

A case of ultrasonographic prenatal diagnosis of conjoined thoraco-omphalopagus twins is reported at the fifteenth week of amenorrhea. Ultrasonography is the only mean of antepartum diagnosis of conjoined twins; Several diagnostic criteria are recalled as well as etiopathogenic and epidemiological considerations of this rare malformation which may concern 1/15.000 to 1/100.