Role of color Doppler in differentiation of Graves' disease and thyroiditis in thyrotoxicosis.

Aim: To evaluate the role of thyroid blood flow assessment by color-flow Doppler ultrasonography in the differential diagnosis of thyrotoxicosis and compare it to technetium pertechnetate thyroid scanning.

Methods: Twenty-six patients with thyrotoxicosis were included in the study. Clinical history was taken and physical examination and thyroid function tests were performed for all patients.

[Graves's disease in children and adolescent: study of seven cases].

Background: In spite of its rarity in the paediatric age, Graves' disease constitutes the principal aetiology of hyperthyroidism in child.

Aim: Our goal is to analyze the clinical and evolutive particularities of Graves's disease in children.

Methods: We studied retrospectively seven cases of Graves' disease in children enrolled in the pediatrics department of Sousse during ten years period (1993-2002).

CYP1A2 genetic polymorphisms and adenocarcinoma lung cancer risk in the Tunisian population.

Aims: In this study, the effects of four single nucleotide polymorphisms (SNPs), -3860G>A, -2467delT, -739T>G and -163C>A, of CYP1A2 gene on lung cancer were evaluated in Tunisian population.

Main Methods: Four polymorphisms of CYP1A2 gene were analysed in 109 healthy smokers and in 101 lung cancer cases, including 63 with squamous cell carcinoma (SCC) and 41 with adenocarcinoma (AD). The genotyping for the SNPs -3860 G>A, -2467delT, -739T>G and -163C>A was performed by polymerase chain reaction (PCR)-restriction fragment length polymorphism analysis.

Preoperative scintigraphic visualization of an orbital metastasis before identification of carcinoma in a nonfunctioning thyroid nodule.

Preoperative accumulation of Tc-99m pertechnetate and radioiodine in metastases of well-differentiated thyroid carcinoma is uncommon. The authors report the case of a 51-year-old woman with follicular thyroid carcinoma revealed by a right orbital metastasis. I-131 scintigraphy performed before thyroidectomy showed intense uptake in an orbital metastasis despite the presence of an intact thyroid gland.

Preoperative scintigraphic visualization of lymph nodes and pulmonary metastases from papillary thyroid carcinoma.

Preoperative accumulation of Tc-99m pertechnetate and radioiodine in metastases of well-differentiated thyroid carcinoma is uncommon. We report herein the case of a 39-year-old woman with occult papillary thyroid cancer revealed by widespread miliary lung metastases. Ultrasonography revealed the presence of an infracentimetric hypoechoic nodule and cervical lymph nodes.

Scintigraphic findings in a case of bilateral urinomas and ascites secondary to posterior urethral valves.

The authors present the scintigraphic findings in a case of bilateral urinomas and ascites secondary to posterior urethral valves in a 9-day-old boy. There was progressive tracer accumulation in the urinomas and ascites with a distinct urine jet medially from the upper left kidney, which suggested direct urinary egress into the peritoneal cavity.

Hypothyroidism presenting as a hot pertechnetate nodule.

The authors report an uncommon finding of hot nodule on Tc-99m sodium pertechnetate thyroid scan in three patients with hypothyroidism. Data indicate that hypothyroidism is secondary to Hashimoto's disease (HD). There was a concordant aspect on I-131 scan in two; a nodular discrepancy (cold nodule with I-131) was associated with the highest microsomal antibodies titer.

Bone scan in initial staging of prostate cancer.

Bone scans of 64 patients with newly diagnosed prostate cancer were retrospectively analysed. Metastases were present in 29 patients (45%). In 75% of these cases, the pattern was manifeastly metastatic.

Incidental discovery of pulmonary metastases during I-131 scintigraphy after total thyroidectomy.

We report the case of a 40-year-old man with radiographically silent pulmonary metastases of papillary thyroid cancer discovered during I-131 scintigraphy following total thyroidectomy performed 10 years after unilateral lobectomy. The residual lobe was histologically normal. After a dose of 11.

Radionuclide bone scan in initial staging of breast cancer.

Radionuclide bone scans of 100 patients with newly diagnosed breast cancer were retrospectively analysed. The number and topography of increased area of uptake were noted. Diagnosis criterion was defined by at least four foci of increased uptake, outside peripheral articular joints.

[Role of iodine-131 in the management of differentiated thyroid cancers (vesicular origin)].

Radioodine-131 has an important place in the management of well-differentiated thyroid cancer. Patient preparation for radioiodine-131 administration must be rigorous and is based on the stimulation of endogenous TSH production, which requires a hypothyroid state after withdrawal of suppressive T4-therapy. The introduction of recombinant human TSH would simplify the protocol of preparation and improve the quality of life of patients.