Author Correction: Convergence of TGFβ and BMP signaling in regulating human bone marrow stromal cell differentiation.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Convergence of TGFβ and BMP signaling in regulating human bone marrow stromal cell differentiation.

Targeting regulatory signaling pathways that control human bone marrow stromal (skeletal or mesenchymal) stem cell (hBMSC) differentiation and lineage fate determination is gaining momentum in the regenerative medicine field. Therefore, to identify the central regulatory mechanism of osteoblast differentiation of hBMSCs, the molecular phenotypes of two clonal hBMSC lines exhibiting opposite in vivo phenotypes, namely, bone forming (hBMSC) and non-bone forming (hBMSC) cells, were studied. Global transcriptome analysis revealed significant downregulation of several TGFβ responsive genes, namely, TAGLN, TMP1, ACTA2, TGFβ2, SMAD6, SMAD9, BMP2, and BMP4 in hBMSC cells and upregulation on SERPINB2 and NOG.