Publications by authors named "Samhita Chaudhuri"
The growing incidence of infections caused by multi-drug resistant Gram-negative bacteria has led to an increased use of last-resort antibiotics such as the polymyxins. Polymyxin therapy is limited by toxicity concerns, most notably nephrotoxicity. Recently we reported the development of a novel class of semisynthetic polymyxins with reduced toxicity wherein the N-terminal lipid and diaminobutyric acid residue are replaced by a cysteine-linked lipid featuring a reductively labile disulfide bond.
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- ET-1 signaling plays a role in regulating intestinal motility and inflammation, primarily through the involvement of enteric glial cells, which influence neural-motor pathways.* -
- The study involved various experimental methods, including the use of ET-related drugs and genetically modified mice, to uncover how ET-1 and its receptors affect calcium responses and motor contractions in the intestines.* -
- Key findings suggest that glial ET signaling inhibits intestinal contractions and peristalsis, especially during inflammation, and that targeted blocking of ET receptors could alleviate intestinal inflammation in specific conditions.*