Novel spirooxindole-triazole derivatives: unveiling [3+2] cycloaddition reactivity through molecular electron density theory and investigating their potential cytotoxicity against HepG2 and MDA-MB-231 cell lines.

A novel analogue of hybrid spirooxindoles was synthesized employing a systematic multistep synthetic approach. The synthetic protocol was designed to obtain a series of spirooxindole derivatives incorporating triazolyl--triazine framework via [3 + 2] cycloaddition (32CA) reaction of azomethine ylide ( with the corresponding chalcones . Unexpectedly, the reaction underwent an alternate route, leading to the cleavage of the s-triazine moiety and yielding a series of spirooxindole derivatives incorporating a triazole motif.

New Functionalized Di-substituent Imidazolium Ionic Liquids as Superior Faster Absorbents for Carbon Dioxide Gas.

Functionalization of room temperature liquids based on disubstituted imidazolium ionic liquids represents a promising avenue for tailoring their tunable physicochemical properties and expanding their potential application as green solvents to capture carbon dioxide as a greenhouse gas. In this work, new hydroxyl functionalized imidazolium ionic liquids were prepared from condensation of ethanolamine with glyoxal and formalin in the presence of acetic acid as catalyst. The chemical modification of the hydroxyl groups with epichlorohydrine added new hydroxylpropanoxychloride groups on the imidazolium cation that were quaternized with -methylimidazolium chloride to produce new imidazolium acetate ionic liquids.

Corrigendum: Pyrazolyl-s-triazine with indole motif as a novel of epidermal growth factor receptor/cyclin-dependent kinase 2 dual inhibitors.

[This corrects the article DOI: 10.3389/fchem.2022.

Pyrazolyl-s-triazine with indole motif as a novel of epidermal growth factor receptor/cyclin-dependent kinase 2 dual inhibitors.

A series of pyrazolyl--triazine compounds with an indole motif was designed, synthesized, and evaluated for anticancer activity targeting dual EGFR and CDK-2 inhibitors. The compounds were tested for cytotoxicity using the MTT assay. Compounds , , and showed promising cytotoxic activity against two cancer cell lines, namely A549, MCF-7, and HDFs (non-cancerous human dermal fibroblasts).

Natural Clay Minerals as Potential Arsenic Sorbents from Contaminated Groundwater: Equilibrium and Kinetic Studies.

Arsenic (As) contaminated groundwater is a worldwide concern due to its chronic effects on human health. The objectives of the study were to evaluate natural inexpensive raw laterite (RL) and kaolinite (RK) for their potential use as As sorbents and to understand the As sorption on laterite and kaolinite by employing sorption and kinetic models. Raw laterite and RK were tested for EC, pH, XRF and CEC as basic parameters.

Correction: Ishaque et al. Iriflophenone-3-C-β-d Glucopyranoside from (Hope) C. Chr. with Promising Future as Natural Antibiotic for Gastrointestinal Tract Infections. 2021, , 1128.

At the request of Dr. Markus Bacher, Dr. Johann Schinnerl, and Dr.

Xanthone C-glycosides isomers purified from (Hope) C. Chr. with bactericidal and cytotoxic prospects.

Xanthones C-glycosides are plants secondary metabolites with diverse biological activities. Among the C-glycoside xanthones, the mangiferin (MF) is of widespread occurrence in plants while isomangiferin (IsoMF) is not very common. For the present study mangiferin (MF) and isomangiferin (IsoMF) were isolated from .

examination and isolation of antidiarrheal compounds using five bacterial strains from invasive species L.

is widely utilized medicinal plant for treatment of diseases like malaria, sore throat, acute nephritis and dysentery. However, despite its traditional uses is not widely explored for its antimicrobial effect. Thus, the current study is aimed to form antimicrobial activity report of extracts, along with isolation and evaluation of antibacterial activity of the isolated compounds through bioassay-guided purification.

Therapeutic prospects of endophytic species from against oxidative stress and microbial pathogens.

Endophytes are microorganisms residing within plant tissues. Bacterial endophytes are important sources for production of pharmaceutically important metabolites. is an important medicinal plant and there exist no report regarding isolation and determination of bioactive potential of its bacterial endophytes.

Fungicidal synergistic effect of biogenically synthesized zinc oxide and copper oxide nanoparticles against causing citrus black rot disease.

Citrus black rot disease being caused by is a major disease of citrus plants with 30-35% economic loss annually. Fungicides had not been effective in the control of this disease during last few decades. In the present study, antifungal role of green synthesized zinc oxide (ZnO) and copper oxide (CuO) nanoparticles (NPs) were studied against .

Pharmacological properties of biogenically synthesized silver nanoparticles using endophyte extract of against oxidative stress and pathogenic multidrug-resistant bacteria.

The emergence of multidrug resistance in pathogenic bacteria limits the utilization of available antibiotics. The development of alternate options to treat infectious diseases is the need of the day.The present study was aimed to synthesize, characterize and evaluate the bioactive properties of silver nanoparticles.

Biological Transformation of Zearalenone by Some Bacterial Isolates Associated with Ruminant and Food Samples.

Zearalenone (ZEA) is a secondary metabolite produced by spp., the filamentous fungi. Food and feed contamination with zearalenone has adverse effects on health and economy.

Mechanism of rice bran lipase inhibition through fermentation activity of probiotic bacteria.

Rice bran oil is known as wonder oil and it is the most important vegetable oil in Asia. Rice bran oil is extracted from bran that is the outer hard layer of rice. It is an emerging category in edible oil with a lot of nutritional properties and health benefits.

Iriflophenone-3-C-β-d Glucopyranoside from (Hope) C. Chr. with Promising Future as Natural Antibiotic for Gastrointestinal Tract Infections.

Ethnopharmacological approaches provide clues for the search of bioactive compounds. (Hope) C. Chr.

Improvement in drought tolerance in bread wheat is related to an improvement in osmolyte production, antioxidant enzyme activities, and gaseous exchange.

Water deficit stress negatively affects wheat growth, physiology, and yield. In lab and hydroponic experiments, osmotic stress levels (control, -2, -4, -6 and -8 Bars) created by PEG-6000, caused a significant decline in germination, mean germination time, root, shoot, and coleoptile length in both wheat genotypes examined. Germination was inhibited more in Wafaq-2001 than in Chakwal-50.

Functional crosstalk between cardiac fibroblasts and adult cardiomyocytes by soluble mediators.

Aims: Crosstalk between cardiomyocytes and fibroblasts in physiological conditions and during disease remains poorly defined. Previous studies have shown that fibroblasts and myocytes interact via paracrine communication, but several experimental confounding factors, including the use of immature myocytes and the induction of alpha-smooth muscle actin (α-SMA) expression in fibroblasts by prolonged culture, have hindered our understanding of this phenomenon. We hypothesize that fibroblasts and myofibroblasts differentially affect cardiomyocytes viability, volume, and Ca(2+) handling via soluble mediators.

Adult human heart slices are a multicellular system suitable for electrophysiological and pharmacological studies.

Electrophysiological and pharmacological data from the human heart are limited due to the absence of simple but representative experimental model systems of human myocardium. The aim of this study was to establish and characterise adult human myocardial slices from small patients' heart biopsies as a simple, reproducible and relevant preparation suitable for the study of human cardiac tissue at the multicellular level. Vibratome-cut myocardial slices were prepared from left ventricular biopsies obtained from end-stage heart failure patients undergoing heart transplant or ventricular assist device implantation, and from hearts of normal dogs.