Facile and efficient synthesis of new class of imidazole derivatives via one-pot multicomponent reactions in water.

A water-accelerated multicomponent synthesis of organic target molecules has been used as a key method for the preparation of novel imidazole derivatives. The three-component condensation reactions of primary amines with trichloroacetonitrile in the presence of ninhydrine in water are developed as efficient and clean green synthetic procedures for the high-yielding preparation of imidazoles.

Multicomponent reactions for the synthesis of functionalized imidazoles.

An efficient synthesis of functionalized tetrahydroimidazoles via a one-pot tandem reaction between ninhydrin, primary alkylamines, arylisocyanates or arylisothiocyanates, acetylenic esters and triphenylphosphine is described.

Synthesis of functionalized 1,2,4-triazole-3-thiones from ammonium isothiocyanate, acid chlorides, and arylhydrazines.

An efficient synthesis of 1-aryl-5-aryl(alkyl)-1,2-dihydro-3H-1,2,4-triazole-3-thiones via reaction between ammonium thiocyanate, acid chlorides, and arylhydrazines is described.

Diastereoselective synthesis of fused [1,3]thiazolo[1,3]oxazins and [1,3]oxazino[2,3-b][1,3]benzothiazoles.

An efficient diastereoselective synthesis of 7-ethyl 5,6-dialkyl 7H-[1,3]thiazolo[2,3-b][1,3]oxazin-5,6, 7-tricarboxylates and 2-ethyl 3,4-dialkyl 2H-[1,3]oxazino [2,3-b][1,3]benzothiazole-2,3,4-tricarboxylates via reaction of thiazole and benzothiazole with dialkyl acetylenedicarboxylates in the presence of ethyl pyruvate is described.