Predictive value of immunohistochemical expression of claudin-1 in colonic carcinoma.

Objective: Colonic carcinoma is one of the most common cancers worldwide. Recently, the possible involvement of claudin-1, one of the major tight junction proteins, in the process of tumorigenesis has been suggested. Also, claudin-1 has emerged as a potential prognostic factor in different types of tumors.

Lateral internal sphincterotomy for chronic idiopathic anal fissure: an alternative approach.

Background: An alternative approach to lateral internal sphincterotomy in the management of chronic anal fissure is presented and its potential advantages are described.

Methods: Using the conventional diathermy, the internal sphincter along with its overlying anoderm is cut to the caudal border of the dentate line.

Results: This prospective study included 350 patients.