The potential role of Epstein-Barr Virus in breast cancer development.

We are looking into viral components that may contribute to breast cancer in order to find possible therapeutic targets. The Epstein-Barr virus (EBV), which has been found to cause nasopharyngeal carcinoma and Burkitt lymphoma, is thought to play a role in breast cancer. Our series' patients had a median age of 49, with nearly half being under the age of 49.

Characterizing EBV-associated Gastric Carcinoma (EBVaGC): A deep dive into LMP1 expression patterns.

Gastric cancer (GC) is a serious public health issue due to its frequency and severity. It is, for both sexes, one of the most common causes of cancer-related death and is a major contributor to the global burden of disease. Recent data show that Epstein-Barr virus (EBV) has been detected in different histopathological subtypes of gastric carcinoma and that EBV-associated gastric carcinoma (EBVaGC) represents about 10% of all cases.

Revealing how phenytoin triggers liver damage and the potential protective effects of Balanites Aegyptiaca fruit extracts: Exploring Nrf2/MAPK/ Beclin-1 signaling pathways.

Phenytoin-induced liver injury (PHT ILII) is a serious condition that may necessitate discontinuation of the drug. This study investigates the mechanisms of PHT ILII and evaluates the protective effects of Balanites Aegyptiaca (BA) fruit extracts on the liver. We focus on the Nrf2/MAPK/NF-κB/Beclin-1 signaling pathways involved in oxidative stress and inflammation from drug-induced liver injury.

A multi-class deep learning model for early lung cancer and chronic kidney disease detection using computed tomography images.

Lung cancer is a fatal disease caused by an abnormal proliferation of cells in the lungs. Similarly, chronic kidney disorders affect people worldwide and can lead to renal failure and impaired kidney function. Cyst development, kidney stones, and tumors are frequent diseases impairing kidney function.

Fabrication of Cr-ZnFeO/S-g-CN Heterojunction Enriched Charge Separation for Sunlight Responsive Photocatalytic Performance and Antibacterial Study.

There has been a lot of interest in the manufacture of stable, high-efficiency photocatalysts. In this study, initially Cr doped ZnFeO nanoparticles (NPs) were made via surfactant-assisted hydrothermal technique. Then Cr-ZnFeO NPs were modified by incorporating S-g-CN to enhance their photocatalytic efficiency.

Boosted spatial charge carrier separation of binary ZnFeO/S-g-CN heterojunction for visible-light-driven photocatalytic activity and antimicrobial performance.

A potential method for removing toxins from contaminated wastewater, especially organic pollutants, is photo-catalysis. Here, a simple technique for producing zinc ferrite nanoparticles (ZnFeO NPS) with varying quantities of sulphur doped graphitic carbon nitride nanocomposites (ZnFeO/S-g-CN NCs) has been described. Then, using X-ray diffraction (XRD), TEM, EDX, XPS, photocurrent response, EIS, and Fourier Transform Infrared spectroscopy (FT-IR), the photo-catalytic activity of the produced nanoparticles (NPs) and nanocomposites (NCs) was examined and evaluated.

Fabrication and Evaluation of Voriconazole Loaded Transethosomal Gel for Enhanced Antifungal and Antileishmanial Activity.

Voriconazole (VRC) is a broad-spectrum antifungal agent belonging to BCS class II (biopharmaceutical classification system). Despite many efforts to enhance its solubility, this primary issue still remains challenging for formulation scientists. Transethosomes (TELs) are one of the potential innovative nano-carriers for improving the solubility and permeation of poorly soluble and permeable drugs.

Immunological characterization of the chemically prepared ghosts of Salmonella Typhimurium as a vaccine candidate.

Background: Bacterial ghosts are the evacuated bacterial cellular membranes from most of the genetic and protein contents which preserved their surface characters. Recently, bacterial ghosts exploited for different biomedical applications, for instance, vaccination. The purpose of this study is to measure the immunogenic protective response of bacterial ghosts of Salmonella Typhimurium in animals and to allow future testing this response in humans.

Salmonella-innovative targeting carrier: Loading with doxorubicin for cancer treatment.

Cell- based targeted delivery is recently gain attention as a promising platform for delivery of anticancer drug in selective and efficient manner. As a new biotechnology platform, bacterial ghosts (BGs) have novel biomedical application as targeted drug delivery system (TDDS). In the current work, Salmonellas' BGs was utilized for the first time as hepatocellular cancer (HCC) targeted delivery system.

A novel protocol for bacterial ghosts' preparation using tween 80.

Bacterial ghosts (BGs) can be prepared by both genetic and chemical means. Genetic method include using lysis gene . Chemical method include incubation with numerous agents for a short time at their minimum inhibitory or minimum growth concentrations (MIC or MGC).