Nanoparticle wrapping at small non-spherical vesicles: curvatures at play.

Nanoparticles in biological systems encounter lipid-bilayer membranes as barriers. They interact with plasma membranes, membranous organelles, such as the endoplasmic reticulum and the Golgi apparatus, the nucleus, and intracellular and extracellular vesicles, such as autophagosomes, lysosomes, and exosomes. Extracellular vesicles have recently attracted particular attention, as they are involved in the transmission of biological signals and as regulators for biological processes.

Preparation, characterization and biodistribution in quails of Tc-folic acid/chitosan nanostructure.

Chitosan (CS) of low molecular weight is prepared using γ-irradiation method in presence of HO as oxidizing agent. The chemical treatment of folic acid (FA) with low molecular weight CS is carried out to prepare FACS complex based on the reaction between NH group of CS and γ-COOH group of FA. The structure and properties of FACS complex was characterized by FT-IR, H NMR, UV, SEM, TEM, DLS and XRD analyses.