Publications by authors named "Sameh Lotfi"
Article Synopsis
- The cytokine IL-32 is found at high levels in HIV-1-infected individuals, but its role is complex as it can both inhibit and stimulate HIV-1 production in different types of immune cells.
- IL-32 inhibits HIV-1 in monocyte-derived macrophages (MDMs) through the activation of SAMHD1, but this effect is lost when SAMHD1 is depleted, distinguishing its action from that in CD4 T cells.
- Additionally, IL-32 promotes immunosuppressive molecules and enhances MDM motility, suggesting that its overall impact may favor the progression of HIV-1 infection despite some inhibitory effects.
Article Synopsis
- Human T-cell leukemia virus type 1 (HTLV-1) primarily spreads between cells, and the protein M-Sec is crucial for this process.
- In HTLV-1 carriers, CD4+ T cells express M-Sec, which is induced by the viral protein Tax, while T cells from non-carriers do not show this expression.
- Reducing M-Sec levels leads to decreased viral infection and impacts cellular structures necessary for the virus, suggesting M-Sec enhances viral spread through promoting membrane protrusions and Gag protein clustering.
Article Synopsis
- HIV-1 enhances the formation of tunneling nanotubes (TNTs) in cells, which helps in transmitting the virus between macrophages, and this process is influenced by the protein M-Sec.
- The study found that when M-Sec is present, HIV-1 increases the number and size of TNTs in U87 cells, leading to better viral transmission, but knocking down M-Sec slows down viral production.
- The research suggests that M-Sec is crucial for both creating TNTs and facilitating the movement of cells, making it a key player in the early stages of HIV-1 infection.
Solid-waste management is associated with several health hazards, particularly parasitic infection. The objective of the study was to determine the association between risk factors and the occurrence of intestinal parasitic infections (potentially pathogenic) among municipal waste collectors in Alexandria, Egypt. A cross-sectional survey was conducted in the main municipality company in Alexandria.
View Article and Find Full Text PDFBackground: Solid waste management has emerged as an important human and environmental health issue. Municipal solid waste workers (MSWWs) are potentially exposed to a variety of occupational biohazards and safety risks. The aim of this study was to describe health practices and safety measures adopted by workers in the main municipal company in Alexandria (Egypt) as well as the pattern of the encountered work related ill health.
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