Immunomodulatory Activity and Inhibitory Effects of Viscum album on Cancer Cells, Its Safety Profiles and Recent Nanotechnology Development.

has been employed traditionally to treat various ailments including as add-on therapy for cancer treatment. formulations have been employed as adjuvants in cancer treatment due to their immunomodulatory activities as well as to alleviate the side effects of conventional cancer therapies. The present review provides updated information from the past 10 years on the immunomodulatory activity and inhibitory effects of on cancer cells, its safety profile, and recent nanotechnology development.

Lamiide and Ipolamiide: A Comprehensive Review of Their Bioactive Properties and Therapeutic Potential.

There is an increasing interest in using iridoids and secoiridoids as major targets for chemical synthesis and biosynthesis. Iridoids can be found in numerous species of Lamiaceae, Verbenaceae, Scrophulariaceae, and other families. Iridoids possess a chemical structure characterized by a cyclopentane ring with oxidative substituents, forming a six-membered ring.

Nutritional, Antioxidant, Antimicrobial, and Anticholinesterase Properties of : A Study Supported by Spectroscopic and Computational Investigations.

Dietary fruits and vegetables play a vital role as food and drugs and are the main sources of antioxidant defences against degenerative diseases, such as brain dysfunctions, cardiovascular diseases, immune system deteriorations, and cancers, brought on by oxidative damage. is a significant herbal remedy used in conventional medicine to recover lost strength and power. In this research, the potential value of as a food and drug is researched.

Characterization of Promising Cytotoxic Metabolites from Hemsl.: Computational Prediction and In Vitro Testing.

Genus is famous for its traditional uses and valuable phytoconstituents. Our previous investigation of species noted the promising anticancer activity of Hemsl. leaves extract, however, the mechanism underlying the observed anticancer activity is still unexplored.

Digalloyl Glycoside: A Potential Inhibitor of Trypanosomal PFK from J.F. Gmel.

Human African trypanosomiasis is an endemic infectious disease caused by via the bite of tsetse-fly. Most of the drugs used for the treatment, e.g.

Antitrypanosomal activity of new semi-synthetic bergenin derivatives.

Bergenin and 11-O-(4'-O-methyl galloyl)-bergenin, previously isolated from Crassula capitella extract, were used as starting materials for the synthesis of eight derivatives; four derivatives 2a-2d were synthesized from bergenin through the formation of ester derivatives and four alkyl derivatives 4a-4d were synthesized from 11-O-(4'-O-methyl galloyl)-bergenin. The structures of the synthesized analogues were confirmed upon H and C NMR spectroscopic elucidation. Antileishmanial and antitrypanosomal activities of the synthesized derivatives were evaluated, compounds 11-O-(3',5' di-benzyl, 4'-O-methyl galloyl)-8,10-di-O-benzyl-bergenin (4c) and 11-O-(3',5'di-4-chlorobenzyl,4'-O-methyl galloyl)-8,10di-O-4-chlorobenzyl bergenin (4d) showed potent antitrypanosomal activity with IC values of 0.

Silybum marianum total extract, silymarin and silibinin abate hepatocarcinogenesis and hepatocellular carcinoma growth via modulation of the HGF/c-Met, Wnt/β-catenin, and PI3K/Akt/mTOR signaling pathways.

Hepatocellular carcinoma (HCC) has been identified as one of the most deadly malignancies with limited therapeutic efficacy worldwide. However, understanding the molecular mechanisms of crosstalk between signaling pathways in HCC and predicting cancer cell responses to targeted therapeutic interventions remain to be challenge. Thus, in this study, we aimed to evaluate the anticancerous efficacy of Silybum marianum total extract (STE), silymarin (Sm), and silibinin (Sb) against experimentally-induced HCC in rats.

Tackling of Renal Carcinogenesis in Wistar Rats by Total Extract, Silymarin, and Silibinin Modulation of Oxidative Stress, Apoptosis, Nrf2, PPAR, NF-B, and PI3K/Akt Signaling Pathways.

The present work was designed to assess the efficacy of total extract (STE), silymarin (Sm), and silibinin (Sb) against experimentally induced renal carcinogenesis in male Wistar rats and their roles in regulating oxidative stress, inflammation, apoptosis, and carcinogenesis. The diethylnitrosamine (DEN)/2-acetylaminofluorene (AAF)/carbon tetrachloride (CCl)-administered rats were orally treated with STE (200 mg/kg b.w.

Use of Medicinal Plants for Respiratory Diseases in Bahawalpur, Pakistan.

The most common ethnomedicinal plants being effective in respiratory disorders were studied for the first time in Bahawalpur District. The herbal medication represents a low-cost treatment for the local community. There is a need for documenting the traditional uses of plants for further investigation of bioactive compounds.

Metabolic profiling of cytotoxic metabolites from five Tabebuia species supported by molecular correlation analysis.

Tabebuia is the largest genus among the family Bignoniaceae. Tabebuia species are known for their high ornamental and curative value. Here, the cytotoxic potential of extracts from the leaves and stems of five Tabebuia species was analyzed.

Production of isoquinoline alkaloids from the conserved and their wound healing activity.

Lam. is a rare herbaceous annual plant, with a well-known richness of isoquinoline alkaloids. It is threaten due to expansion on construction in the Mediterranean coastal region.

Metabolomic profiling, biological evaluation of , the river Nile-derived fungus using epigenetic and OSMAC approaches.

LC-HRMS-based metabolomics approach was applied to the river Nile-derived fungus after its fermentation on four different media and using four epigenetic modifiers as elicitors. Thereafter, a comprehensive multivariate statistical analysis such as PCA, PLS-DA and OPLS-DA were employed to explain the generated metabolomic data (1587 features). PCA showed that the fungus displayed a unique chemical profile in each medium or elicitor.

Nuclear Magnetic Resonance Metabolomics Approach for the Analysis of Major Legume Sprouts Coupled to Chemometrics.

Legume sprouts are a fresh nutritive source of phytochemicals of increasing attention worldwide owing to their many health benefits. Nuclear magnetic resonance (NMR) was utilized for the metabolite fingerprinting of 4 major legume sprouts, belonging to family Fabaceae, to be exploited for quality control purposes. Thirty-two metabolites were identified belonging to different classes, i.

Cytotoxic Activity and Metabolic Profiling of Fifteen Species.

is a large genus of flowering plants with a great diversity in metabolic pattern. Testing the cytotoxic potential of fifteen species revealed highest activity of L. against CACO2 cell line (IC 7.

An Up-to-Date Review on Citrus Flavonoids: Chemistry and Benefits in Health and Diseases.

Flavonoids, the main class of polyphenols, are characterized by the presence of 2-phenyl-benzo-pyrane nucleus. They are found in rich quantities in citrus fruits. Citrus flavonoids are classified into flavanones, flavones, flavonols, polymethoxyflavones and anthocyanins (found only in blood oranges).

Docking studies of sesquiterpene lactones isolated from L. reveals their potential anti-inflammatory and cytotoxic activities.

Five sesquiterpene lactones were isolated and identified from L. Hymenin showed highest cytotoxic activity against HCT-116, A-549, and MCF-7 cell lines (IC= 3.83 ± 0.

The genus as a model microorganism for bioactive natural product discovery.

This review covers the development of the genus as a model for natural product research and the timeline of discovery progress from the classical bioassay-guided approaches through the application of genome mining and genetic engineering techniques that target specific products. It focuses on the reported chemical structures along with their biological activities and the synthetic and biosynthetic studies they have inspired. This survey summarizes the extraordinary biosynthetic diversity that can emerge from a widely distributed actinomycete genus and supports future efforts to explore under-explored species in the search for novel natural products.

Salicylic acid increases flavonolignans accumulation in the fruits of hydroponically cultured .

(L.) Gaertn. (Asteraceae) was hydroponically cultured using a nutrient film technique system.

Studies on essential oil from rose-scented geranium, L'Hérit. (Geraniaceae).

Rose-scented geranium, L'Hérit. (Geraniaceae), is an economically important plant. GC-MS analysis of the essential oil, prepared by hydro-distillation from this plant species, showed the presence of iso-menthone (15.

Cytotoxic, hepatoprotective and antioxidant activities of variety growing in Egypt.

Silymarin prepared from the fruits of (L.) Gaertn. (Asteraceae) has long been used for the treatment of liver disorders.

Linear regression analysis of silychristin A, silybin A and silybin B contents in .

Quantitative correlations between the contents of the flavonolignans silychristin A and silybins A/B provide biosynthetic clues that support a pathway in which one mesomeric form of a taxifolin radical is undergoing an oxidative coupling with a coniferyl alcohol radical. The flavonolignan content and patterns reported in the literature for 53 samples, representing populations of the plant growing in different parts of the world, were subject to a meta-analysis. Linear regression analyses were carried out on these data sets, and a mathematical model was derived that predicts the content of silychristin A relative to the metabolomic pattern of its congeners.

Monoamine oxidases inhibitors from Colvillea racemosa: Isolation, biological evaluation, and computational study.

Bioassay-guided fractionation and chemical investigation of Colvillea racemosa stems led to identification of two new α, β-dihydroxydihydrochalcones, colveol A (1) and colveol B (2) along with fifteen known compounds. The structures were elucidated via interpretation of spectroscopic data. The absolute configurations of the dihydrochalcones 1 and 2 were assigned by a combination of chemical modification and electronic circular dichroism data.

Secondary metabolites from fungal endophytes of Solanum nigrum.

Three endophytic fungi, Aspergillus sp. (SNFSt), Aspergillus sp. (SNFL) and Lasiodiplodia theobromae (SNFF) were isolated from stems, leaves and fruits of Solanum nigrum L, respectively.

Chemotaxonomic and biosynthetic relationships between flavonolignans produced by Silybum marianum populations.

Flavonolignans constitute an important class of plant secondary metabolites formed by oxidative coupling of one flavonoid and one phenylpropanoid moiety. The standardized flavonolignan-rich extract prepared from the fruits of Silybum marianum is known as silymarin and has long been used medicinally, prominently as an antihepatotoxic and as a chemopreventive agent. Principal component analysis of the variation in flavonolignan content in S.