Development and evaluation of a pilot overdose education and naloxone distribution program for hospitalized general medical patients.

Overdose education and naloxone distribution (OEND) to people at risk of witnessing or experiencing an opioid overdose has traditionally been provided through harm reduction agencies. Expanding OEND to inpatient general medical settings may reach at-risk individuals who do not access harm reduction services and have not been trained. An OEND program targeting inpatients was developed, piloted, and evaluated on 2 general medicine floors at Montefiore Medical Center, a large urban academic medical center in Bronx, New York.

Epidemiology of CTX-M-type extended-spectrum β-lactamase-producing Escherichia coli among older adults.

To identify independent predictors for isolation of CTX-M-type extended-spectrum β-lactamase-producing Escherichia coli (CTX-M E coli) in older adults (>65 years old), 87 cases with CTX-M E coli isolation were compared with matched controls without E coli isolation. Institutionalized residence, multiple comorbidities, and urinary catheter were independent predictors of CTX-M E coli among older adults.

Extended-spectrum β-lactamase-producing Escherichia coli isolation among older adults: epidemiology and outcomes.

Clinical outcomes of older and younger adults with extended-spectrum β-lactamase-producing Escherichia coli isolation were compared. Two hundred thirty-two older adults (aged ≥65 years), and 145 younger adults with infection were identified between February 2010 and July 2011. After controlling for the propensity score and receipt of effective therapy, older adults were not at increased risk for adverse outcomes.