Salivary malondialdehyde in oral submucous fibrosis - A marker for oxidative damage.

Background: Oral submucous fibrosis (OSMF) is a potentially malignant disorder of oral mucosa and its malignant transformation rate accounts to about 7%-13%. Oxidative damage and lipid peroxidation plays an important role in OSMF. Lipid peroxidation has not been widely investigated in OSMF patients with respect to clinical staging and histopathological grading.

Estimation of serum sialic acid in oral submucous fibrosis and oral squamous cell carcinoma.

Background And Objectives: Sialic acid (SA) N-acetyl neuraminic acid is a negatively charged 9-carbon monosaccharide, commonly attached to the nonreducing residues of carbohydrate chains of glycoconjugates by glycosidic linkage. SA is widely distributed in glycoproteins (GPs) of cell membrane. The alterations in GPs start at an early stage of tumorigenesis.

Solitary plasmacytoma of mandible: A rare entity.

Plasmacytoma is a discrete, unifocal, monoclonal neoplastic proliferation of the plasma cells. It may present as one of the three distinct clinical entities: multiple myeloma (MM), solitary plasmacytoma of bone and extramedullary plasmacytoma. Solitary bone plasmacytoma accounts for 3% of all plasma cell neoplasms with approximately 50% of the cases transforming into MM.

Natural substitutes for formalin: A boon to histopathology!!

Introduction: In routine tissue processing, formalin has been proved as efficient as fixative since inception and hazards associated with it are of major safety and health concern.

Aim: The aim of this study is to compare the efficacy of natural fixatives such as jaggery and Khandsari over formalin.

Materials And Methods: Ninety normal tissue specimen collected during minor oral surgical procedures were included in this study.