Publications by authors named "Samara Bray"
Over the past 10 years, there has been limited progress for the treatment of brain cancer and outcomes for patients are not much improved. For brain cancer researchers, a major obstacle to biomarker driven research is limited access to brain cancer tissue for research purposes. The Mark Hughes Foundation Brain Biobank is one of the first post-mortem adult brain banks in Australia to operate with protocols specifically developed for brain cancer.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates DNA methylation profiles in CD4 T cells of progressive multiple sclerosis (MS) patients, aiming to understand the pathology of the disease.
- It identifies three differentially methylated regions (DMRs) in genes HTR2A, SLC17A9, and HDAC4 that are consistent across two study cohorts, with HTR2A showing significant methylation differences independent of genetic variations.
- The findings suggest that HTR2A's differential methylation could serve as a potential biomarker for progressive MS, distinguishing it from relapsing-remitting MS (RRMS), as no expression changes were detected in the DMRs.