Publications by authors named "Samar S Elshazly"
Article Synopsis
- The study evaluated the expression of five long non-coding RNAs (HOTAIR, MALAT-1, XIST, SNHG15, and H19) in patients with diffuse large B-cell lymphoma (DLBCL) to investigate their relationship with various clinical features.
- Results indicated that HOTAIR was significantly elevated while SNHG15 was downregulated in DLBCL patients, with both showing potential as distinguishing biomarkers between those with DLBCL and healthy individuals.
- The findings suggest that specific lncRNAs could aid in diagnosing and staging DLBCL, as well as predicting patient outcomes, warranting further research to understand their long-term impact on survival and disease progression.
Aim: was to assess the role of C-KIT, TET1 and TET2 expression in the diagnosis and prognosis of acute myeloblastic leukemia (AML).
Methods: The expression levels of C-KIT, TET1 and TET2 were assessed in the bone marrow (BM) aspirate of 152 AML patients compared to 20 healthy control using quantitative real-time polymerase chain reaction (qRT-PCR). Data were correlated with the clinico-pathological features of the patients, response to treatment, disease-free survival (DFS), and overall survival (OS) rates.
Long noncoding RNAs (lncRNAs) are evolving as contributing biomarkers for many diseases. Among these lncRNAs, X inactive-specific transcript (XIST), and nuclear paraspeckle assembly transcript 1 (NEAT1) were studied as undesirable upregulated nucleic acid markers for unfavorable prognosis of cancer. The authors aimed to investigate their role as diagnostic markers for breast cancer (BC) patients with high-risk factors.
View Article and Find Full Text PDFBackground: The expression of β-catenin and paired-like homeobox 2B (PHOX2B) expression were assessed in Neuroblastoma (NB) patients as a diagnostic, prognostic and/or predictive markers.
Methods: Bone marrow (BM) samples of 52 NB patients were assessed for the expression of β-catenin by immunohistochemistry (IHC), and PHOX2B by real time PCR (RT-PCR), compared to 12 healthy normal controls (NC). The data were correlated to the clinic-pathological features of the patients, response to treatment and disease relapse.