Publications by authors named "Samar Nabil ElAchy"
Article Synopsis
- - Toxoplasmosis is a significant zoonotic disease with challenges in treatment, particularly when the parasite becomes inactive in tissues, making current drugs less effective.
- - The study explored the effectiveness of the antiretroviral drug Aluvia (lopinavir/ritonavir) against the cystogenic Me49 strain of Toxoplasma in mice, comparing it to traditional treatments like pyrimethamine-sulfadiazine at different stages of infection.
- - Results showed that L/R significantly reduced the cyst burden in brain tissue and improved neuro-inflammation, although it didn't fully normalize cytokine levels, indicating it has potential for treating chronic cerebral toxoplasmosis.
Aims: Cerium oxide nanoparticles (CeONPs) have been recently introduced into the medical field for their antioxidant properties. The ability of CeONPs alone or in combination with spironolactone (SP) to attenuate monocrotaline (MCT)-induced pulmonary hypertension and associated right ventricular hypertrophy was studied in rats. A special emphasis was given to endothelin-1 pathway.
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