Synopsis of recent research by authors named "Samanthula Gananadhamu"
- Samanthula Gananadhamu's recent research primarily focuses on the stability and degradation of pharmaceutical compounds, employing advanced analytical techniques such as liquid chromatography, high-resolution mass spectrometry, and nuclear magnetic resonance spectroscopy to characterize degradation impurities in drugs like upadacitinib, ubrogepant, and mavacamten.
- The studies highlight the forced degradation conditions (hydrolysis, oxidation, thermal, and photolysis) for various medications, adhering to International Council for Harmonisation guidelines, which aids in understanding their stability and ensuring safety and quality in drug development.
- Additionally, Gananadhamu explores the role of in silico approaches for predicting toxicity and degradation products, augmenting experimental methodologies, and providing insight into innovative drug formulations, including the use of covalent organic frameworks in the pharmaceutical sector.
