Publications by authors named "Samantha St Jean"
Radiolabeled small-molecule DOTA-haptens can be combined with antitumor/anti-DOTA bispecific antibodies (BsAbs) for pretargeted radioimmunotherapy (PRIT). For optimized delivery of the theranostic γ- and β-emitting isotope Lu with DOTA-based PRIT (DOTA-PRIT), bivalent Gemini (DOTA-Bn-thiourea-PEG4-thiourea-Bn-DOTA, aka (3,6,9,12-tetraoxatetradecane-1,14-diyl)bis(DOTA-benzyl thiourea)) was developed. Gemini was synthesized by linking 2 -2-(4-isothiocyanatobenzyl)-DOTA molecules together via a 1,14-diamino-PEG4 linker.
View Article and Find Full Text PDFDysregulated epigenetic states are a hallmark of cancer and often arise from genetic alterations in epigenetic regulators. This includes missense mutations in histones, which, together with associated DNA, form nucleosome core particles. However, the oncogenic mechanisms of most histone mutations are unknown.
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- Researchers have used the murine bacterial pathogen (Cm) to study human Chlamydia infections in mice, focusing on the role of immune responses in controlling these infections.
- In 2022, it was found that natural Cm infections are occurring in mouse colonies worldwide, a significant discovery since such infections hadn't been documented in lab mice since the 1940s.
- A study involving severely immunocompromised mice showed that direct contact with Cm-infected mice led to serious health issues, including pneumonia and intestinal colonization, highlighting the pathogen's impact on vulnerable populations.
A 3-year-old castrated male, American Pit Bull Terrier presented to Texas A&M University due to a 3-week mixed cerebellar and general proprioceptive ataxia, circling, head tilt, and dull mentation. Neurologic examination revealed signs of vestibular and mesencephalic dysfunction. Postmortem examination revealed a 1.
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- Collaboration with the American College of Veterinary Pathologists aims to enhance veterinary education and training.
- The partnership focuses on improving the standards of veterinary pathology.
- This initiative is designed to support research and advancements in veterinary medicine.
Canine multiple system degeneration (CMSD) is a progressive hereditary neurodegenerative disorder commonly characterized by neuronal degeneration and loss in the cerebellum, olivary nuclei, substantia nigra, and caudate nuclei. In this article, we describe 3 cases of CMSD in Ibizan hounds. All patients exhibited marked cerebellar ataxia and had cerebellar atrophy on magnetic resonance imaging.
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