Characterizing supplement use and dietary behaviors in adults with acquired brain injury.

Background: Acquired brain injury (ABI) can result in persistent symptoms and lasting disability. Supplements are becoming more popular in patients with chronic symptoms; however, little is known about supplementation and dietary behaviors after ABI.

Methods: In this cross-sectional observational study, questionnaires were collected from 211 adults with ABI presenting to outpatient brain injury clinics.

Effect of Aerobic Exercise on Symptom Burden and Quality of Life in Adults With Persisting Post-concussive Symptoms: The ACTBI Randomized Controlled Trial.

Objective: To evaluate a 6-week sub-symptom threshold aerobic exercise protocol (AEP) versus a stretching protocol (SP) on symptom burden and quality of life (QoL) in adults with persisting post-concussive symptoms (PPCS).

Design: The Aerobic exercise for treatment of Chronic symptoms following mild Traumatic Brain Injury (ACTBI) Trial was a randomized controlled trial with 2 groups.

Setting: Outpatient brain injury, pain, and physiotherapy clinics.

Assessment of sleep parameters in adults with persistent post-concussive symptoms.

Objectives: The primary aim of this study was to characterize sleep in adults with persistent post-concussive symptoms (PPCS). Secondary aims explored relationships between sleep parameters, injury characteristics, and symptom questionnaires.

Methods: This case-controlled, cross-sectional study recruited adults (18-65yrs) diagnosed with PPCS and age and sex-matched controls.

New insights into visually impaired patients' preferred reading illumination and home-based reading speed with new task-lighting.

Introduction: When optimal lighting is applied to hard-copy materials for visually impaired individuals, laboratory-based reading performance can improve significantly. However, it is not known whether their lighting preferences are related to ocular factors or if laboratory-based reading improvements will translate to home-based environments.

Methods: Preferences for brightness (lux) and colour temperature (degrees Kelvin; K) with the LuxIQ/2 for 'most comfort' while reading at near were evaluated in-clinic for 71 adults with ocular disease affecting the outer (n = 37; 52%), inner or all retinal layers (n = 34; 48%).

Atypical Exophytic Retinal Capillary Hemangioma and Diagnostic Modalities.

Purpose: Retinal capillary hemangioma (RCH) can occur in isolation or may be associated with von Hippel-Lindau disease. The classic RCH is described as a globular reddish lesion with a dilated feeding artery and a tortuous draining vein, indicative of a common endophytic growth pattern. Exophytic patterns are far more rare and, because of its subtle appearance, often missed or misdiagnosed.

First report of warfarin dose requirements in patients possessing the CYP2C9*12 allele.

Background: Warfarin is the most frequently prescribed anticoagulant in North America and Europe. It is administered as a racemate, but S-warfarin is principally responsible for its anticoagulant activity. Cytochrome P450 (CYP) 2C9 is the enzyme primarily responsible for the metabolism of S-warfarin.

Changing Behavior among Nurses to Track Indwelling Urinary Catheters in Hospitalized Patients.

Catheter-associated urinary tract infections (CAUTIs) are preventable complications of hospitalization. An interdisciplinary team developed a curriculum to increase awareness of the presence of indwelling urinary catheters (IUCs) in hospitalized patients, addressed practical, primarily nurse-controlled inpatient risk-reduction interventions, and promoted the use of the IUC labels ("tags"). Five thirty-minute educational sessions were cycled over three daily nursing shifts on two inpatient medical floors over a 1-year period; participants were surveyed (n = 152) to elicit feedback and provide real-time insight on the learning objectives.

Biophysical analysis of binding of WW domains of the YAP2 transcriptional regulator to PPXY motifs within WBP1 and WBP2 adaptors.

The YAP2 transcriptional regulator mediates a plethora of cellular functions, including the newly discovered Hippo tumor suppressor pathway, by virtue of its ability to recognize WBP1 and WBP2 signaling adaptors among a wide variety of other ligands. Herein, using isothermal titration calorimery and circular dichroism in combination with molecular modeling and molecular dynamics, we provide evidence that the WW1 and WW2 domains of YAP2 recognize various PPXY motifs within WBP1 and WBP2 in a highly promiscuous and subtle manner. Thus, although both WW domains strictly require the integrity of the consensus PPXY sequence, nonconsensus residues within and flanking this motif are not critical for high-affinity binding, implying that they most likely play a role in stabilizing the polyproline type II helical conformation of the PPXY ligands.