Publications by authors named "Samantha Mao"
Background/purpose: Alzheimer's disease (AD) is a neurodegenerative disorder and the most common form of dementia. The etiology for AD includes age, genetic susceptibility, neuropathology, and infection. Periodontitis is an infectious and inflammatory disease which mainly causes alveolar bone destruction and tooth loss.
View Article and Find Full Text PDFApart from aging process, adult intervertebral disc (IVD) undergoes various degenerative processes. However, the nicotine has not been well identified as a contributing etiology. According to a few studies, nicotine ingestion through smoking, air or clothing may significantly accumulate in active as well as passive smokers.
View Article and Find Full Text PDFArticle Synopsis
- MTHFD2 is highly expressed in lung cancer (LCa) and is associated with poor survival outcomes; the study aimed to explore its metabolic functions and effects on cellular behavior.
- Researchers confirmed MTHFD2 levels in LCa tissues and cell lines, using gene knockdown to assess changes in cell viability, transformation, and self-renewal.
- Findings revealed that knocking down MTHFD2 reduced these abilities and tumor growth in mice, indicating that targeting MTHFD2 could impede LCa progression through metabolic reprogramming.