A local-scale One Health genomic surveillance of demonstrates highly related strains from humans, canines, and the environment.

Although infections caused by have historically been attributed to hospital acquisition, growing evidence supports the role of community acquisition in infection (CDI). Symptoms of CDI can range from mild, self-resolving diarrhoea to toxic megacolon, pseudomembranous colitis, and death. In this study, we sampled from clinical, environmental, and canine reservoirs in Flagstaff, Arizona, USA, to understand the distribution and transmission of the pathogen in a One Health framework; Flagstaff is a medium-sized, geographically isolated city with a single hospital system, making it an ideal site to characterize genomic overlap between sequenced isolates across reservoirs.

Identification of novel, cryptic species isolates from environmental samples collected from diverse geographical locations.

is a pathogen often associated with hospital-acquired infection or antimicrobial-induced disease; however, increasing evidence indicates infections can result from community or environmental sources. Most genomic sequencing of has focused on clinical strains, although evidence is growing that spores are widespread in soil and water in the environment. In this study, we sequenced 38 genomes collected from soil and water isolates in Flagstaff (AZ, USA) and Slovenia in an effort targeted towards environmental surveillance of .