Cystathionine gamma-lyase deficiency exaggerates diethylnitrosamine-induced liver damage in mice.

Cystathionine gamma-lyase (CSE) is a key enzyme in reverse transsulfuration pathway and contributes to the majority of HS generation in liver tissues via cysteine metabolism. Dysfunction of the CSE/HS system is linked to both chronic and acute liver damage. This study investigated the regulatory role of CSE deficiency on diethylnitrosamine (DEN)-induced liver damage in mice.

An evolutionary perspective on the interplays between hydrogen sulfide and oxygen in cellular functions.

The physiological effects of the endogenously generated hydrogen sulfide (HS) have been extensively studied in recent years. This review summarized the role of HS in the origin of life and HS metabolism in organisms from bacteria to vertebrates, examined the relationship between HS and oxygen from an evolutionary perspective and emphasized the oxygen-dependent manner of HS signaling in various physiological and pathological processes. HS and oxygen are inextricably linked in various cellular functions.