Publications by authors named "Samantha L Budd Haeberlein"
Activation of the c-Jun N-terminal kinase (JNK) pathway is suggested to be required for neuronal apoptosis. We investigated the role of JNK on phosphorylation of c-Jun, Bcl-2, and apoptotic translocation of cytochrome c (cyt c) in UV-induced apoptosis in human neuroblastoma SH-SY5Y cells. We confirm that UV irradiation induces both apoptosis and necrosis in SH-SY5Y cells and that phosphorylation of JNK at Thr183/Tyr185 in SH-SY5Y cells treated with UV is an early event preceding apoptosis.
View Article and Find Full Text PDFAbstract Glycogen synthase kinase3 (GSK3) is emerging as a prominent drug target in the CNS. The most exciting of the possibilities of GSK3 lies within the treatment of Alzheimer's disease (AD) where abnormal increases in GSK3 levels and activity have been associated with neuronal death, paired helical filament tau formation and neurite retraction as well as a decline in cognitive performance. Abnormal activity of GSK3 is also implicated in stroke.
View Article and Find Full Text PDFArticle Synopsis
- An extensive study was conducted on fetal mouse brain cell aggregates using advanced techniques like immunohistochemistry and stereology, revealing detailed characteristics of these cells.
- The cell aggregates formed quickly in culture and mainly consisted of neurons, along with astrocytes, microglia, and oligodendrocytes, indicating a diverse cell population.
- The research discovered that neural precursor cells could be isolated and differentiated into various neuron types, making this aggregate culture system a valuable tool for studying brain processes in mouse models.
Migration and differentiation of neural precursor cells can be directed by microglia.
Proc Natl Acad Sci U S A
December 2003
Recent reports have supported the existence of neural stem cells in the adult mammalian CNS. Important features of such cells are self-renewal and multipotency, i.e.
View Article and Find Full Text PDF