Publications by authors named "Samantha Koh"
Feasibility, reliability and validity of self-measurement of knee range-of-motion using an accelerometer-based smartphone application by patients with total knee arthroplasty.
PLoS One
October 2024
Article Synopsis
- After knee surgery, many people struggle to move their knees properly, which can make them unhappy and limit their activities.
- This study looked at whether patients could accurately measure their knee movement using a special app on their smartphones instead of needing a healthcare professional.
- The results showed that almost all patients could use the app easily, and it gave very reliable measurements of knee movement.
Objective: To determine, in patients undergoing total knee arthroplasty (TKA), whether increasing context specificity of selected items of the shortened version of the Western Ontario and McMaster Universities Osteoarthritis Index function (WOMAC-F) scale (ShortMAC-F) (1) enhanced the convergent validity of the ShortMAC-F with performance-based mobility measures (ii) affected mean scale score, structural validity, reliability, and interpretability.
Design: Secondary analysis of randomized clinical trial data.
Setting: A tertiary teaching hospital.
Article Synopsis
- Triple-negative breast cancer (TNBC) has a high risk of recurrence and generally poor outcomes, with traditional treatment mainly involving chemotherapy, but newer options like immunotherapy are becoming available.
- The response to treatment in TNBC varies significantly among patients, and many subtypes develop resistance early, often due to dysfunctional senescent cells that can lead to worse prognosis.
- Current research aims to target these senescent cells and improve treatment strategies, but there are challenges such as the right treatment timing and understanding the specific vulnerabilities of patients.
Using personal protective equipment (PPE) can reduce risk of disease transmission. During the COVID-19 pandemic, enhanced PPE (EPPE) is recommended when performing endoscopy. We aimed to evaluate the impact of EPPE on colonoscopy performance when compared to standard PPE (SPPE).
View Article and Find Full Text PDFBackground: Although the US Food and Drug Administration (FDA) recommended upper limits for citalopram dosing in older adults due to risk of corrected-QT (QTc) prolongation, which was adopted, and extended to escitalopram by Health Canada, the scientific basis is unclear. The objective of this study was to assess the relationship between citalopram/escitalopram dosages and QTc interval in a real-world geriatric setting.
Methods: We reviewed electronic health records at a university-affiliated geriatric health care center, over a 7-year period, to identify patients prescribed citalopram and escitalopram, who had an ECG within 90 days of initiation or dosage change.
Chronic hepatitis B virus (HBV) infection is one of the most associated factors in hepatocarcinogenesis. HBV is able to integrate into the host genome and encode the multi-functional hepatitis B virus x protein (HBx). Although the mechanism between HBx and carcinogenesis is still elusive, recent studies have shown that HBx was able to influence various signaling pathways, as well as epigenetic and genetic processes.
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