Publications by Samantha Kearney

Publications by authors named "Samantha Kearney"

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Glucocorticoids modify effects of TGF-β1 on multidrug resistance in the fetal blood-brain barrier.

Stephanie Baello Majid Iqbal Samantha Kearney Shikah Kuthiala Enrrico Bloise

Growth Factors

February 2016

Transforming growth factor-β1 (TGF-β1) increases P-glycoprotein (P-gp; encoded by Abcb1) activity in fetal brain endothelial cells (BECs). P-gp is important for fetal brain protection against xenobiotics including synthetic glucocorticoids (sGC). We hypothesized that antenatal sGC would modify P-gp responsiveness to TGF-β1 in fetal BECs.

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