Publications by authors named "Samantha K D'Spain"
Article Synopsis
- Membrane contact sites (MCS) are essential for communication between organelles, facilitated by the interaction between the endoplasmic reticulum (ER) protein VAP and proteins containing FFAT motifs.
- The bacterium in question utilizes a tether, IncV, which mimics the FFAT motif to establish MCS with the ER, and its assembly is regulated by phosphorylation events mediated by host cell kinases.
- IncV's phosphorylation enhances its interaction with the inclusion membrane and allows it to fully mimic the function of eukaryotic FFAT motifs, showcasing how pathogens adapt eukaryotic mechanisms for their benefit.
