Publications by authors named "Samantha H Dallefeld"
Sedative and Analgesic Pharmacokinetics During Pediatric ECMO.
J Pediatr Pharmacol Ther
November 2020
Sedatives and analgesics are often administered to critically ill children supported by extracorporeal membrane oxygenation (ECMO) to facilitate comfort and to decrease risks of life-threatening complications. Optimization of sedative and analgesic dosing is necessary to achieve desired therapeutic benefits and must consider interactions between the circuit and patient that may affect drug metabolism, clearance, and impact on target organs. This paper reviews existing and pediatric literature concerning the effects of the ECMO circuit on sedative and analgesic disposition and offers dosing guidance for the management of critically ill children receiving these drugs.
View Article and Find Full Text PDFBackground: Dexmedetomidine is a sedative administered to minimize distress and decrease the risk of life threatening complications in children supported with extracorporeal membrane oxygenation. The extracorporeal membrane oxygenation circuit can extract drug and decrease drug exposure, placing the patient at risk of therapeutic failure.
Objective: To determine the extraction of dexmedetomidine by the extracorporeal membrane oxygenation circuit.
Article Synopsis
- Amiodarone is a crucial antiarrhythmic medication for serious heart issues in children, but its pharmacokinetics in this age group are not well understood.
- A population pharmacokinetic model was created by analyzing blood samples from infants under 2 years old who received the drug, combining data from a recent study and existing literature.
- The final model, which included body weight as a variable, revealed important metrics like clearance and volume of distribution, providing valuable insights for optimizing amiodarone dosages in young patients.