Publications by authors named "Samantha Guild"

To describe progression, content, and stringency of state legislation regulating indoor tanning and association with state government political party leadership. Trained research assistants used legal mapping methods to code legislative bills on indoor tanning introduced in US states, the District of Columbia, and Puerto Rico. We calculated composite scores on the stringency of age restrictions and of warnings, operator requirements, and enforcement.

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The NCCN Guidelines for Cutaneous Melanoma (termed Melanoma: Cutaneous) provide multidisciplinary recommendations for diagnostic workup, staging, and treatment of patients. These NCCN Guidelines Insights focus on the update to neoadjuvant systemic therapy options and summarize the new clinical data evaluated by the NCCN panel for the recommended therapies in Version 2.2024 of the NCCN Guidelines for Cutaneous Melanoma.

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Article Synopsis
  • The article provides updated guidelines for clinicians on systemic therapy options for melanoma, based on a systematic review by the American Society of Clinical Oncology Expert Panel.
  • New recommendations include using neoadjuvant pembrolizumab for resectable stage IIIB to IV melanoma, and adjuvant nivolumab or pembrolizumab for stage IIB-C disease.
  • Additionally, certain older treatments are no longer recommended for specific melanoma types, and new options are suggested for unresectable or metastatic cases.
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Importance: A key issue for the adjuvant treatment of patients with melanoma is the assessment of the effect of treatment on relapse, survival, and quality of life (QOL).

Objective: To compare QOL in patients with resected melanoma at high risk for relapse who were treated with adjuvant pembrolizumab vs standard of care with either ipilimumab or high-dose interferon α 2b (HDI).

Design, Setting, And Participants: The S1404 phase 3 randomized clinical trial was conducted by the SWOG Cancer Research Network at 211 community/academic sites in the US, Canada, and Ireland.

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Purpose: Combination programmed cell death protein 1/cytotoxic T-cell lymphocyte-4-blockade and dual BRAF/MEK inhibition have each shown significant clinical benefit in patients with -mutant metastatic melanoma, leading to broad regulatory approval. Little prospective data exist to guide the choice of either initial therapy or treatment sequence in this population. This study was conducted to determine which initial treatment or treatment sequence produced the best efficacy.

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Over the past few years, the NCCN Guidelines for Melanoma: Cutaneous have been expanded to include pathways for treatment of microscopic satellitosis (added in v2.2020), and the following Principles sections: Molecular Testing (added in v2.2019), Systemic Therapy Considerations (added in v2.

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Article Synopsis
  • The text outlines guidance for clinicians on the use of systemic therapy for melanoma based on a systematic review and meta-analysis.
  • It includes recommendations for treating different melanoma stages, specifying therapies for both wild-type and mutant cutaneous melanoma.
  • Additionally, it mentions the lack of specific recommendations for neoadjuvant therapy and uveal melanoma, while suggesting that mucosal melanoma patients may receive similar treatments as those with cutaneous melanoma.
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Several states have passed legislation banning minors from indoor tanning; however, concern has been raised regarding enforcement. We explored the statutes pertaining to enforcement in the first 6 US states to pass legislation banning minors younger than 18 years from indoor tanning. The findings reflect significant variability in enforcement provisions across the 6 states.

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On June 1, 2011, the California Senate passed a bill banning minors from indoor tanning. We aimed to determine whether the bill's passage was associated with longer-term media coverage regarding skin protection and the risks associated with indoor tanning. Articles from 31 English-language California newspapers between June 2010-May 2011 (PRE) and June 2011-May 2012 (POST) were searched using terms related to skin protection.

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