Publications by authors named "Samantha Betters"
Article Synopsis
- Chronic low-grade inflammation is linked to motivational deficits in major depression, impacting patients' quality of life.
- A study tested the anti-inflammatory drug infliximab on 42 unmedicated major depression patients, finding it improved their willingness to exert effort for rewards compared to a placebo.
- Changes in effort-based decision-making were associated with reduced inflammatory markers and modulated brain activity related to reward processing, suggesting anti-inflammatory treatments could enhance motivation in depressed individuals with high inflammation.
Chronic, low-grade inflammation has been associated with motivational deficits in patients with major depression (MD). In turn, impaired motivation has been linked to poor quality of life across psychiatric disorders. We thus determined effects of the anti-inflammatory drug infliximab-a potent tumor necrosis factor (TNF) antagonist-on behavioral and neural measures of motivation in 42 medically stable, unmedicated MD patients with a C-reactive protein > 3mg/L.
View Article and Find Full Text PDF