Publications by authors named "Samantha A O'Connor"
Article Synopsis
- Single-cell transcriptomics reveals diverse cellular behavior, with a focus on the importance of cell cycle stages in human neural stem cells.
- The ccAFv2 classifier categorizes cells into six distinct cell cycle states and a quiescent-like state, outperforming existing methods while offering flexibility and customizable classifications.
- Demonstrated effectiveness across different cell types and species, ccAFv2 is accessible as an R package and a Python package, making it a valuable resource for analyzing complex biological data and understanding cellular dynamics.
Somatic mutations occur as random genetic changes in genes through protein-affecting mutations (PAMs), gene fusions, or copy number alterations (CNAs). Mutations of different types can have a similar phenotypic effect (i.e.
View Article and Find Full Text PDFArticle Synopsis
- Amyotrophic Lateral Sclerosis (ALS) is a complicated neurodegenerative disease that varies widely among patients in terms of age of onset, progression of symptoms, treatment effectiveness, and overall disease duration.
- A study was conducted using brain tissue samples from 208 ALS patients to analyze these variations and understand the underlying pathology better, focusing on the role of transposable elements (TEs) in the disease.
- The researchers identified three distinct molecular subtypes of ALS patients, each linked to different survival outcomes, indicating that various mechanisms may contribute to the clinical differences seen in ALS.
Article Synopsis
- The perivascular niche (PVN) is a key area in glioblastoma that helps glioma stem cells (GSCs) survive and promote tumor recurrence, making understanding its cellular interactions important for creating effective treatments.
- Research has revealed limitations in current models for studying the PVN, prompting the development of a new organotypic triculture microfluidic model that includes endothelial cells (ECs), astrocytes, and GSCs to better investigate their interactions.
- The study found that ECs and astrocytes enhance GSC invasiveness and identified 15 significant ligand-receptor pairs, including the SAA1-FPR1 pair, which could be targets for new therapeutic approaches in treating glioblastoma.
Single-cell RNA sequencing has emerged as a powerful tool for resolving cellular states associated with normal and maligned developmental processes. Here, we used scRNA-seq to examine the cell cycle states of expanding human neural stem cells (hNSCs). From these data, we constructed a cell cycle classifier that identifies traditional cell cycle phases and a putative quiescent-like state in neuroepithelial-derived cell types during mammalian neurogenesis and in gliomas.
View Article and Find Full Text PDF