Publications by authors named "Samantha A Betters"
Mol Psychiatry
September 2024
Article Synopsis
- Chronic low-grade inflammation is linked to motivational deficits in major depression, impacting patients' quality of life.
- A study tested the anti-inflammatory drug infliximab on 42 unmedicated major depression patients, finding it improved their willingness to exert effort for rewards compared to a placebo.
- Changes in effort-based decision-making were associated with reduced inflammatory markers and modulated brain activity related to reward processing, suggesting anti-inflammatory treatments could enhance motivation in depressed individuals with high inflammation.
