An insight into the role of ESIPT/TICT-based antioxidant flavone analogues in fluoro-probing diabetes-induced viscosity changes: a unified experimental and theoretical endeavour.

Potent antioxidants, like 3-hydroxy flavones, attracted considerable attention due to their excited state intramolecular proton transfer (ESIPT)-based fluorescence behaviour. This article is an interesting demonstration of a series of synthetic 3-hydroxy flavone analogues having high antioxidant activity as molecular rotor-like viscosity probes. Among these flavone analogues, 4'-N,N-dimethylamino-3-hydroxy flavone (3) is the most potent one, showing the twisted intramolecular charge transfer (TICT)-dependent fluoroprobing activity toward the blood viscosity changes associated with diabetes and free fatty acids (FFA)-induced nuclear viscosity changes of MIN6 cells.

Large-Scale Mechanochemical Synthesis of Cesium Lanthanide Chloride for Radioluminescence.

Cesium lanthanide chloride (CsLnCl), a recently developed class of lanthanide-based zero-dimensional metal halides, has garnered a significant amount of interest because of its potential applications in scintillators, light-emitting diodes, and photodetectors. Although cesium lanthanide chloride demonstrates exceptional scintillator properties, conventional synthesis methods involving solid-state and solution-phase techniques are complex and limited on the reaction scale. This study presents a facile mechanochemical synthesis method for producing CsCeCl, CsTbCl, and CsEuCl metal halides on a 5 g scale.

Cold Seeded Epitaxy and Flexomagnetism in GdAuGe Membranes Exfoliated From Graphene/Ge(111).

Remote and van der Waals epitaxy are promising approaches for synthesizing single crystalline membranes for flexible electronics and discovery of new properties via extreme strain; however, a fundamental challenge is that most materials do not wet the graphene surface. We develop a cold seed approach for synthesizing smooth intermetallic films on graphene that can be exfoliated to form few nanometer thick single crystalline membranes. Our seeded GdAuGe films have narrow X-ray rocking curve widths of 9-24 arc seconds, which is 2 orders of magnitude lower than their counterparts grown by typical high temperature methods, and have atomically sharp interfaces observed by transmission electron microscopy.

Arsenic Induced Oxidative Neural-Damages in Rat are Mitigated by Tea-Leave Extract via MMPs and AChE Inactivation, Shown by Molecular Docking and in Vitro Studies with Pure Theaflavin and AChE.

Background: Chronic arsenic-exposure causes neuromuscular disorders and other health anomalies. Damage to DNA and cytoskeletal/extracellular matrix is brought on by reactive-oxygen-species (ROS)-induced intrinsic antioxidant depletion (thiols/urate). Therapeutic chelating-agents have multiple side-effects.

Highly Emissive Lanthanide-Based 0D Metal Halide Nanocrystals for Efficient Ultraviolet Photodetector.

Recently, lanthanide-based 0D metal halides have attracted considerable attention for their applications in X-ray imaging, light-emitting diodes (LEDs), sensors, and photodetectors. Herein, lead-free 0D gadolinium-alloyed cesium cerium chloride (Gd-alloyed CsCeCl) nanocrystals (NCs) are introduced as promising materials for optoelectronic application owing to their unique optical properties. The incorporation of Gd in CsCeCl (CCC) NCs is proposed to increase the photoluminescence quantum yield (PLQY) from 57% to 96%, along with significantly enhanced phase and chemical stability.

Caprolactone-Based Biodegradable Polymer for Selective, Sensitive Detection and Removal of Cu Ions from Water.

Even though heavy and transition metals originated in the earth's crust, the significant human exposure and environmental pollution consequences of anthropogenic activities include industrial production and waste, mining and smelting operations, and agricultural and domestic usage of metals. Because of their nonbiodegradable nature, heavy metal ions such as Cu accumulate very quickly in plants and edible animals, ultimately ending up in the human food cycle. Therefore, to nullify the detrimental effects of Cu ions for the sake of the environment and living organisms, we are motivated to design a sensor molecule that can not only detect Cu ions but also remove them selectively from the water medium.

CD24 negativity reprograms mitochondrial metabolism to PPARα and NF-κB-driven fatty acid β-oxidation in triple-negative breast cancer.

CD24 is a well-characterized breast cancer (BC) stem cell (BCSC) marker. Primary breast tumor cells having CD24-negativity together with CD44-positivity is known to maintain high metastatic potential. However, the functional role of CD24 gene in triple-negative BC (TNBC), an aggressive subtype of BC, is not well understood.

Intermediate phase between jammed and unjammed amorphous solids.

A significant amount of attention was dedicated in recent years to the phenomenon of jamming of athermal amorphous solids by increasing the volume fraction of the microscopic constituents. At a critical value of the volume fraction, pressure shoots up from zero to finite values with a host of critical exponents discovered and discussed. In this paper, we advance evidence for the existence of a second transition, within the jammed state of two-dimensional granular systems, that separates two regimes of different mechanical responses.

Biodegradable Solid Polymer Electrolytes from the Discarded Cataractous Eye Protein Isolate.

The protein extracted from the discarded eye lenses postcataract surgery, referred to as the cataractous eye protein isolate (CEPI), is employed as a polymer matrix for the construction of solid polymer electrolyte species (SPEs). SPEs are expected to be inexpensive, conductive, and mechanically stable in order to be economically and commercially viable. Environmentally, these materials should be biodegradable and nontoxic.

Unique Reaction-Based Polynorbornene Sensing Probes for Ultrasensitive Detection of Hydrazine in Both Environmental and Biological Systems.

Hydrazine-mediated formation of 1,4-phthalazinedione analogues from phthalimide-like components has been utilized to formulate fluorescent probe . A turn-on fluorescent process has been evaluated to detect hydrazine in a highly selective manner by a small molecular probe and its homopolymer . Both these probes have been evaluated as excellent candidates for nanomolar level detection of hydrazine with a time frame of <15 min, which is rapid in terms of real application.

Unravelling the Metal Sensing Activity of a Biologically Relevant Fluorescent Crown Ether: A Unified Experimental and Theoretical Study.

1,4-dihydropyridines (DHPs) are biologically active. 1,4-DHP analogs with appropriate substituents also show characteristic fluorescence activity. Here, for the first time, we report a simple and easy synthesis of a novel fluorescent 1,4- DHP derivative of dibenzo[18]-crown-6 (2), which showed promising sensing ability towards physiologically important metal ions.

Third Agers in India: Empirical Evidence From Longitudinal Aging Study in India (LASI), 2017-2018.

Given that the ontological origins of the Third Age lie in the cultural logics of social class, consumer society and "habitus," a majority of its gerontological examination is qualitative in nature. We utilize the recently released Longitudinal Aging Study in India (2017-2018) and harness the time-use module to offer an empirical portrait of Third Agers in India. Considering that the aging scholarship in India has been often articulated in the empirical language of dependency, care regimes, and (economic) insecurity, we believe this examination allows us to shift the gerontological gaze from a risk perspective to one that is positive and affirmative.

Social egg freezing as ambivalent materialities of aging.

This commentary explores how the material-nonmaterial transactions around reproduction among women raise paradoxical questions of reproductive autonomy and commercialization of reproduction. Drawing from medical anthropological studies on human reproduction, the technology around social egg freezing has been conceived to proffer ambivalent possibilities of hope, despair, and repair as mature women recalibrate their reproductive identities, especially in pronatalist contexts. Building on the material-discursive critique of the 'material turn', I ask if social egg freezing offers an empowering biological reprieve for women who have 'chosen' a non-normative (i.

Metabolomic Rewiring Promotes Endocrine Therapy Resistance in Breast Cancer.

Unlabelled: Approximately one-third of endocrine-treated women with estrogen receptor alpha-positive (ER+) breast cancers are at risk of recurrence due to intrinsic or acquired resistance. Thus, it is vital to understand the mechanisms underlying endocrine therapy resistance in ER+ breast cancer to improve patient treatment. Mitochondrial fatty acid β-oxidation (FAO) has been shown to be a major metabolic pathway in triple-negative breast cancer (TNBC) that can activate Src signaling.

Leisure as social engagement: does it moderate the association between subjective wellbeing and depression in later life?

Objectives: To investigate the role of leisure (as social engagement) in moderating the association between subjective wellbeing and depressive symptoms among older Indians.

Methods: The sample included data from 39,538 older adults (aged 55-80) from the Longitudinal Aging Study in India (LASI, Wave-1), 2017-2018. Individual level questionnaire was used to examine the relationship among social engagement, subjective wellbeing, and depressive symptoms.

Comparative Cytogenetics and Fluorescent Chromosome Banding in Five Indian Species of Medik.

The genus Medik. (Subfamily: Scilloideae) has a narrow distribution in India and several overlapping morphological traits make the genus taxonomically challenging at the species level. Cytogenetic characterization can provide additional taxonomic data and can be used to evaluate genetic diversity at the species level.

Intense Hydrochromic Photon Upconversion from Lead-Free 0D Metal Halides For Water Detection and Information Encryption.

Hydrochromic materials that change their luminescence color upon exposure to moisture have attracted considerable attention owing to their applications in sensing and information encryption. However, the existing materials lack high hydrochromic response and color tunability. This study reports the development of a new and bright 0D Cs GdCl metal halide as the host for hydrochromic photon upconversion in the form of polycrystals (PCs) and nanocrystals.

Efficient Quantification of Extrinsic Fluctuations via Stochastic Simulations.

At the molecular level, all the biological processes are exposed to fluctuations emanating from various sources in and around the cellular system. Often these fluctuations dictate the outcome of a cell-fate decision-making event. Thus, having an accurate estimate of these fluctuations for any biological network is extremely important.

"I Don't Want to Have the Time When I Do Nothing": Aging and Reconfigured Leisure Practices During the Pandemic.

In this paper, we contend that urban middle-class older Indians engaged in "serious leisure" as a way to reimagine and reconfigure the structure of everyday life during the pandemic-led epochal downtime. In particular, we heuristically show that leisure activity patterns and constraint negotiation strategies among older Indians followed conceptual semblances with the dominant leisure-based typology of . By thematically analysing household surveys (n = 71), time-use diaries and in-depth interviews (n = 15) of middle to upper middle-class individuals (55-80 years), we show how both men and women distinguished between serious leisure that is marked by motivation, agency and perseverance with that of unstructured, routinized free-time (or causal leisure).

Comparative transcriptome analysis reveals an insight into the candidate genes involved in anthocyanin and scent volatiles biosynthesis in colour changing flowers of Combretum indicum.

Combretum indicum is a widely cultivated ornamental species displaying the distinct phenomenon of floral colour change. Flowers display a gradual colour change from white to red, attributed to increased cyanidin 3-O glucoside in petal tissues. The differently coloured flowers also emanate a complex blend of VOCs with trans-linalool oxide (furanoid) as the major compound in the emission profile.

Blocked by Gender: Disparities in COVID19 infection detection in Tamil Nadu, India.

Globally, a gender gap in COVID-19 has been noted with men reporting higher share of both morbidity and deaths compared to women. While the gender gap in fatalities has been similar across the globe, there have been interesting disparities in the detection of COVID-19 cases in men and women. While wealthier, more developed nations have generally seen similar case detection in men and women, LMICs especially in Asia have seen far greater proportion of COVID-19 cases among men than women.

Searching for a Solar Source of Magnetic-Field Switchbacks in Parker Solar Probe's First Encounter.

Parker Solar Probe observations show ubiquitous magnetic-field reversals closer to the Sun, often referred to as "switchbacks". The switchbacks have been observed before in the solar wind near 1 AU and beyond, but their occurrence was historically rare. PSP measurements below ∼ 0.

Ionic mobility driven by correlated van der Waals and electrostatic forces.

Classical theories of dielectric friction make two critical assumptions: (i) friction due to van der Waals (vdW) forces is described by hydrodynamic drag and is independent of the ionic charge and (ii) vdW and electrostatic forces are statistically independent. Both assumptions turn out to be incorrect when tested against simulations of anions and cations with varying charge magnitude dissolved in water. Both the vdW and electrostatic components of the force variance scale linearly with the ionic charge squared.

Understanding the Role of Stigma and Misconceptions in the Experience of Epilepsy in India: Findings From a Mixed-Methods Study.

It is surprising that although 12 million people in India suffer from epilepsy this remains a thoroughly under-researched area in the sociology of health and practice. We address this intellectual and policy neglect by reviewing the social, psychological and legal challenges governing the lives of people living with epilepsy (PWE) by paying particular attention to negotiations in arranged marriages and employment. Drawing on the analytical frameworks of the sociological study of stigma, critical race theory and paying attention to the cultural models of health and suffering, this study utilized a combination of (online) survey data ( = 100) and in-depth qualitative interviews ( = 10) with PWE and their families.

: Gerontological Reflections on the Life Course Perspective's Missing Plot.

Gyllenhaal's with its deeply troubling, turbulent and yet unwavering chaos allows us to rethink how the past is never really lost. It is in the uneasy dialectic between individual lives, social structures, and emotional states that finds an unexpected gerontological articulation. Specifically, this article utilizes one of the assured tools of gerontology- the life course perspective- to argue that the persisting effects of social-psychological states (e.