Extraction and pre-concentration of parabens in liquid pharmaceutical samples by dispersive liquid-liquid microextraction based on deep eutectic solvents.

In this paper dispersive liquid-liquid microextraction using deep eutectic solvent (DES), as an extraction solvent, was applied for the pre-concentration and determination of parabens in liquid pharmaceutical samples. A DES composed of a hydrogen bond acceptor [choline chloride (ChCl)] and a hydrogen bond donor (glucose) achieved the highest extraction efficiency. Therefore, this solvent was selected as the extraction solvent.