Nitric oxide contributes to learning and memory deficits observed in hypothyroid rats during neonatal and juvenile growth.

Introduction: Severe cognitive impairment follows thyroid hormone deficiency during the neonatal period. The role of nitric oxide (NO) in learning and memory has been widely investigated.

Methods: This study aimed to investigate the effect of hypothyroidism during neonatal and juvenile periods on NO metabolites in the hippocampi of rats and on learning and memory.