Background: Parkinson's disease is the second most common neurodegenerative disorder with complex and distributed motor and non-motor symptoms. In this study, cortical gray matter (GM) and cerebral white matter (WM) overall atrophy, and asymmetry of atrophy are investigated in PD with normal cognitive function.
Method: Forty-eight male Parkinson's disease(PD) patients with normal cognitive precede (PD-NC), and thirty matched healthy control (HC) subjects were selected from the Parkinson's Progression Markers Initiative (PPMI) database.
A novel magnetic ion-imprinted polymer with high accessibility to palladium ions was synthesized via co-precipitation polymerization. Accordingly, a ternary complex composed of PdCl as an imprinting ion, 8-aminoquinoline (AQ) as a ligand, and 4-vinyl pyridine (4-VP) as a complexing monomer was applied to FeO@SiO as magnetic core, followed by precipitation polymerization using 2-hydroxyethyl methacrylate (2-HEMA) as a co-monomer, ethylene glycol dimethacrylate (EGDMA) as the crosslinker, and 2,2-azobisisobutyronitrile (AIBN) as an initiator in the presence of 2-methoxyethanol as a solvent. The palladium ions were leached out by a solution containing 50% (v/v) HCl.
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