Publications by authors named "Samaneh Chaychi"
The high incidence of concussions/mild traumatic brain injury and the significant number of people with persisting concussion symptoms as well as the concern for delayed, neurodegenerative effects of concussions makes them a major public health concern. There is much to learn on concussions with respect to pathophysiology as well as vulnerability and resiliency factors. The heterogeneity in outcome after a concussion warrants a more personalized approach to better understand the biological and psychosocial factors that may affect outcome.
View Article and Find Full Text PDFPurpose: To determine the neuroprotective effect of estrogen on the structure and function of the retina exposed to an oxidative stress.
Methods: Male Sprague-Dawley rat pups were exposed to either hyperoxia (OE: from P8 to P14) or bright light (LE: from P14 to P28) with or without 17 β-estradiol (βE) treatment. Retinal structure (histology) and function (ERG) were assessed at selected time points.
Article Synopsis
- The study examines how biological sex and age impact the retina's structure and function in rodents, particularly focusing on the influence of estrogen during different phases of the estrus cycle in female rats.
- Researchers tested 50 male and female albino Sprague-Dawley rats at various ages, utilizing electroretinogram (ERG) assessments and retinal histology.
- Results indicated age-related changes in retinal function, with premenopausal females showing superior retinal function compared to menopausal females and males, suggesting a positive effect of the estrus cycle on retinal health.
Systemic inflammation perturbs developmental retinal angiogenesis and neuroretinal function.
Invest Ophthalmol Vis Sci
December 2013
Purpose: Perinatal inflammatory stress in preterm babies is associated with increased rates of severe retinopathy of prematurity (ROP) and adverse neurological dysfunction. In this study, we set out to determine the consequences of severe systemic inflammatory stress on developmental retinal vascularization and evaluate the subsequent outcome on retinal function in later life.
Methods: Systemic inflammatory stress was induced in C57BL/6J mouse pups by an intraperitoneal injection of lipopolysaccharide (LPS; 1 mg/kg) at postnatal day 4.