Chronic migraine caused a higher rate of tendency to cannabinoid agonist compared to morphine.

Background And Aim: Opioid and cannabinoid systems have considerable roles in modulation of chronic pain as well as regulation reward circuit and addiction responses. This study investigated the effect of nitroglycerin (NTG)-induced migraine attack on the acquisition of morphine and cannabinoid-induced conditioned place preference (CPP) in male rats.

Methods: Adult male rats (230-250 gr) were used.