Publications by authors named "Saman Sohail"
Staphylococcus aureus (S. aureus) is an opportunistic gram-positive, non-motile, and non-sporulating bacteria that induces pneumonia, a provocative lung infection affecting mainly the terminal bronchioles and the small air sacs known as alveoli. Recently, it has developed antibiotic resistance to the available consortium as per the WHO reports; thereby, novel remedial targets and resilient medications to forestall and cure this illness are desperately needed.
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- * Research was conducted to examine the druggable genome of S. sciuri, identifying three promising gene targets (ArgS, SecY, MurA) linked to antibiotic resistance, and created 3D protein models of these targets.
- * A screening of over 36,000 Traditional Chinese Medicine compounds was performed, with molecular docking revealing how well these compounds fit into the protein targets, while simulations showed how these compounds can influence the structure and stability of the protein-l
Article Synopsis
- Typhoid fever is spread through contaminated food and water, predominantly in developing countries with poor hygiene, prompting research for new treatment options.
- A subtractive genomics approach was used to analyze the genomes of Salmonella Typhi, identifying essential genes and potential drug targets, leading to the creation of 3D protein models for further testing.
- Four promising inhibitors were selected from a large drug-like library after assessing their binding properties, with the goal of developing new therapies alongside current treatments for typhoid Salmonellosis.
Burkholderia cepacia complex (BCC) is a group of gram-negative bacteria composed of at least 20 different species that cause diseases in plants, animals as well as humans (cystic fibrosis and airway infection). Here, we analyzed the proteomic data of 47 BCC strains by classifying them in three groups. Phylogenetic analyses were performed followed by individual core region identification for each group.
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