Disruption of functional network development in children with prenatal Zika virus exposure revealed by resting-state EEG.

Children born to mothers infected by Zika virus (ZIKV) during pregnancy are at increased risk of adverse neurodevelopmental outcomes including microcephaly, epilepsy, and neurocognitive deficits, collectively known as Congenital Zika Virus Syndrome. To study the impact of ZIKV on infant brain development, we collected resting-state electroencephalography (EEG) recordings from 28 normocephalic ZIKV-exposed children and 16 socio-demographically similar but unexposed children at 23-27 months of age. We assessed group differences in frequency band power and brain synchrony, as well as the relationship between these metrics and age.