Publications by authors named "Sam Twongyeirwe"
Article Synopsis
- Ebola disease (EBOD) is a serious illness caused by viruses in the Orthoebolavirus genus, primarily the Ebola virus, posing challenges for public health due to its human-to-human transmission and limited treatment options.
- Despite decades of research, the origins and detailed epidemiology of these viruses remain unclear, with serosurveys indicating higher infection rates than the observed clinical cases.
- Recent work has mapped a specific B-cell epitope in the Ebola virus spike protein, revealing that cross-reactive antibodies provide insight into unexpected seroprevalences and suggest potential improvements in serological specificity for diagnosing EBOD.
Article Synopsis
- The rVSVΔG-ZEBOV-GP vaccine has been used during Ebola outbreaks, and a study in Uganda assessed healthcare workers' knowledge, attitudes, and long-term immune responses following vaccination.
- Out of 565 surveyed healthcare workers, only 37% reported being vaccinated, and a significant portion lacked knowledge that the vaccine only protects against Ebola.
- Despite the general desire for booster doses, the findings highlight the need for continued education on Ebola and other viral hemorrhagic fevers, especially since the vaccine's long-term effectiveness remains uncertain.
