Publications by authors named "Sam Templeman"
Article Synopsis
- Mycobacterium tuberculosis infection leads to significant lung damage due to inflammation in an acidic environment, but the effects of this acidity on immune response were previously unknown.
- Research using RNA-seq revealed that acidosis alters the expression of nearly 4000 genes in infected human macrophages, particularly enhancing pathways for degrading extracellular matrix, which contributes to lung damage in Tuberculosis.
- The study found that acidosis suppresses key cytokines involved in fighting the infection, with specific receptors related to acidosis signaling identified in both mice and TB patients, suggesting these receptors could be targeted for new therapies.
Background: The Central African Republic (CAR) suffers a protracted conflict and has the second lowest human development index in the world. Available mortality estimates vary and differ in methodology. We undertook a retrospective mortality study in the Ouaka prefecture to obtain reliable mortality data.
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